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Titolo:
Iterative reconstruction based on median root prior in quantification of myocardial blood flow and oxygen metabolism
Autore:
Katoh, C; Ruotsalainen, U; Laine, H; Alenius, S; Iida, H; Nuutila, P; Knuuti, J;
Indirizzi:
HokkaidoJapan, Sch Med, Dept Nucl Med, Kita Ku, Sapporo, Hokkaido 0608638,Hokkaido Univ Sapporo Hokkaido Japan 0608638 , Sapporo, Hokkaido 0608638, Tampere Univ Technol, Signal Proc Lab, FIN-33101 Tampere, Finland Tampere Univ Technol Tampere Finland FIN-33101 IN-33101 Tampere, Finland Res Inst Brain & Blood Vessels, Akita, Japan Res Inst Brain & Blood Vessels Akita Japan Blood Vessels, Akita, Japan Turku PET Ctr, Turku, Finland Turku PET Ctr Turku FinlandTurku PET Ctr, Turku, Finland
Titolo Testata:
JOURNAL OF NUCLEAR MEDICINE
fascicolo: 5, volume: 40, anno: 1999,
pagine: 862 - 867
SICI:
0161-5505(199905)40:5<862:IRBOMR>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION TOMOGRAPHY; IMAGE-RECONSTRUCTION; PET; INHALATION; ALGORITHM; STRATEGY;
Keywords:
PET; O-15; iterative reconstruction; myocardial blood flow; myocardial oxygen metabolism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Katoh, C Hokkaido Univ, Sch Med, Dept Nucl Med, Kita Ku, N-15,W-7, Sapporo, Hokkaido Hokkaido Univ N-15,W-7 Sapporo Hokkaido Japan 0608638 o, Hokkaido
Citazione:
C. Katoh et al., "Iterative reconstruction based on median root prior in quantification of myocardial blood flow and oxygen metabolism", J NUCL MED, 40(5), 1999, pp. 862-867

Abstract

The aim of this study was to compare reproducibility and accuracy of two reconstruction methods in quantification of myocardial blood flow and oxygenmetabolism with O-15-labeled tracers and PET. A new iterative Bayesian reconstruction method based on median root prior (MRP) was compared with filtered backprojection (FBP) reconstruction method, which is traditionally usedfor image reconstruction in PET studies. Methods: Regional myocardial blood flow (rMBF), oxygen extraction fraction (rOEF) and myocardial metabolic rate of oxygen consumption (rMMRO(2)) were quantified from images reconstructed in 27 subjects using both MRP and FBP methods. For each subject, regions of interest (ROls) were drawn on the lateral, anterior and septal regionson four planes. To test reproducibility, the ROI drawing procedure was repeated. By using two sets of ROls, variability was evaluated from images reconstructed with the MRP and the FBP methods. Results: Correlation coefficients of significantly higher in the images reconstructed with the MRP reconstruction method compared with the images reconstructed with the FBP method (rMBF: MRP r= 0.896 versus FBP r= 0.737, P< 0.001; rOEF: 0.915 versus 0.855, P < 0.001; rMMRO(2): 0.954 versus 0.885, P < 0.001). Coefficient of variation for each parameter was significantly lower in MRP Images than in FBP images (rMBF: MRP 23.5% +/- 11.3% versus FBP 30.1% +/- 14.7%, P < 0.001; rOEF: 21.0% +/- 11.1% versus 32.1% +/- 19.8%, P <0.001; rMMRO(2): 23.1% +/- 13.2% versus 30.3% +/- 19.1%, P < 0.001). Conclusion: The MRP reconstruction method provides higher reproducibility and lower variability in the quantitative myocardial parameters when compared with the FBP method. This study shows that the new MRP reconstruction method improves accuracy and stabilityof clinical quantification of myocardial blood flow and oxygen metabolism with O-15 and PET.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 18:05:20