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Titolo:
Quantity of human cytomegalovirus (CMV) DNAemia as a risk factor for CMV disease in renal allograft recipients: Relationship with donor/recipient CMVserostatus, receipt of augmented methylprednisolone and antithymocyte globulin (ATG)
Autore:
Hassan-Walker, AF; Kidd, IM; Sabin, C; Sweny, P; Griffiths, PD; Emery, VC;
Indirizzi:
Royal Free & Univ Coll Med Sch, Dept Virol, London, England Royal Free & Univ Coll Med Sch London England pt Virol, London, England Royal Free & Univ Coll Med Sch, Dept Primary Care, London, England Royal Free & Univ Coll Med Sch London England ary Care, London, England Royal Free & Univ Coll Med Sch, Dept Populat Sci, London, England Royal Free & Univ Coll Med Sch London England ulat Sci, London, England RoyalEnglandampstead NHS Trust & Sch Med, Dept Renal Transplantat, London,Royal Free Hampstead NHS Trust & Sch Med London England lantat, London, Royal Free Hampstead NHS Trust & Sch Med, Dialysis Unit, London, England Royal Free Hampstead NHS Trust & Sch Med London England London, England
Titolo Testata:
JOURNAL OF MEDICAL VIROLOGY
fascicolo: 2, volume: 58, anno: 1999,
pagine: 182 - 187
SICI:
0146-6615(199906)58:2<182:QOHC(D>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; TRANSPLANT RECIPIENTS; VIRUS; LOAD; DNA; INFECTION; RETINITIS; BLOOD;
Keywords:
cmv load; cmv DNAemia; quantitative-competitive polymerase chain reaction; cytomegalovirus; antithymocyte globulin; serostatus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Emery, VC RoyaldFree & Univ Coll Med Sch, Dept Virol, Rowland Hill St, London, Englan Royal Free & Univ Coll Med Sch Rowland Hill St London England
Citazione:
A.F. Hassan-Walker et al., "Quantity of human cytomegalovirus (CMV) DNAemia as a risk factor for CMV disease in renal allograft recipients: Relationship with donor/recipient CMVserostatus, receipt of augmented methylprednisolone and antithymocyte globulin (ATG)", J MED VIROL, 58(2), 1999, pp. 182-187

Abstract

A prospective longitudinal study of 87 renal allograft recipients identified 31 patients with cytomegalovirus (CMV) viraemia. Previous studies have identified CMV viraemia, donor positivity, and CMV load in urine as independent risk factors for disease following renal transplantation. We used quantitative-competitive polymerase chain reaction (OC-PCR) to quantify the CMV DNA load in blood from these patients, and report that it is a significant and independent risk factor for CMV disease. Patients with symptomatic CMV infection had significantly higher maximum CMV loads than those with no disease (P = .0003). We also found that peak loads were significantly higher in individuals experiencing primary CMV infection (P < .01), and CMV re-infection (P < .05) compared with recipients reactivating endogenous CMV. Univariate analysis revealed that CMV DNA load in blood, donor seropositivity, and receipt of antithymocyte globulin (ATG) were all significantly associated with disease (P = .005, .04, and .05, respectively). However, the association of donor/recipient serostatus, and receipt of ATG became nonsignificant in multivariate analyses whereas the significance of the quantity of CMV DNAemia was maintained, illustrating that CMV load plays a central role in the pathogenesis of CMV disease. J. Med. Virol. 58:182-187, 1999, (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 23:02:40