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Titolo:
Distribution of GABAergic cells and fibers in the hippocampal formation ofthe macaque monkey: An immunohistochemical and in situ hybridization study
Autore:
Jongen-Relo, AL; Pitkanen, A; Amaral, DG;
Indirizzi:
Univ Calif Davis, Ctr Neurosci, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 is, Ctr Neurosci, Davis, CA 95616 USA Univ Calif Davis, Dept Psychiat, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 s, Dept Psychiat, Davis, CA 95616 USA Univ Kuopio, AI Virtanen Inst, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 nen Inst, FIN-70211 Kuopio, Finland
Titolo Testata:
JOURNAL OF COMPARATIVE NEUROLOGY
fascicolo: 2, volume: 408, anno: 1999,
pagine: 237 - 271
SICI:
0021-9967(19990531)408:2<237:DOGCAF>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTAMIC-ACID DECARBOXYLASE; RAT DENTATE GYRUS; CALCIUM-BINDING PROTEINS; POLYPEPTIDE-IMMUNOREACTIVE INTERNEURONS; SOMATOSTATIN-LIKE IMMUNOREACTIVITY; ENDURING MEMORY IMPAIRMENT; PREFERENTIAL NEURONAL LOSS; MEDIAL ENTORHINAL CORTEX; TEMPORAL-LOBE EPILEPSY; ENCODING 2 FORMS;
Keywords:
dentate gyrus; entorhinal cortex; glutamic acid decarboxylase; parasubiculum; presubiculum; subiculum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
92
Recensione:
Indirizzi per estratti:
Indirizzo: Amaral, DG Univ Calif Davis, Ctr Neurosci, 1544 Newton Court, Davis, CA 95616 USA Univ Calif Davis 1544 Newton Court Davis CA USA 95616 95616 USA
Citazione:
A.L. Jongen-Relo et al., "Distribution of GABAergic cells and fibers in the hippocampal formation ofthe macaque monkey: An immunohistochemical and in situ hybridization study", J COMP NEUR, 408(2), 1999, pp. 237-271

Abstract

The gamma-aminobutyric acid (GABAergic) system of the hippocampal formation of Macaca fascicularis monkeys was studied immunohistochemically with a monoclonal antibody to GABA and with nonisotopic in situ hybridization with cRNA probes for glutamic acid decarboxylase 65 (GAD65) and GAD67. The highest densities of labeled cells were observed in the presubiculum, parasubiculum, entorhinal cortex, and subiculum, whereas the CA3 field and the dentate gyrus had the lowest densities of positive neurons. Within the dentate gyrus, most of the GABAergic neurons were located in the polymorphic layer and in the deep portion of the granule cell layer. GABAergic terminals were densest in the outer two-thirds of the molecular layer. GABAergic neurons were seen throughout all layers of the hippocampus. Terminal labeling was highest in the stratum lacunosum-moleculare. A higher terminal labeling was observed in the subiculum than in CA1 and was particularly prominent in layerII of the presubiculum. A bundle of GABAergic fibers was visible deep to the cell layers of the presubiculum and subiculum. This bundle could be followed into the angular bundle ipsilaterally and was continuous with stained fibers in the dorsal hippocampal commissure. This pattern of labeling is reminiscent of the presubicular projections to the contralateral entorhinal cortex. GABAergic cells were observed in all layers of the entorhinal cortexalthough the density was higher in layers II and III than in layers V and VI. The in situ hybridization preparations largely confirmed the distribution of GABAergic neurons in all fields of the hippocampal formation. J. Comp. Neurol. 408:237-271, 1999. (C) 1999 Wiley-Liss, Inc.

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Documento generato il 19/01/20 alle ore 14:32:10