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Titolo:
Autoradiographic and in situ hybridization localization of corticotropin-releasing factor 1 and 2 receptors in nonhuman primate brain
Autore:
Sanchez, MM; Young, LJ; Plotsky, PM; Insel, TR;
Indirizzi:
Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 ychiat & Behav Sci, Atlanta, GA 30322 USA Emory Univ, Yerkes Reg Primate Res Ctr, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 eg Primate Res Ctr, Atlanta, GA 30322 USA
Titolo Testata:
JOURNAL OF COMPARATIVE NEUROLOGY
fascicolo: 3, volume: 408, anno: 1999,
pagine: 365 - 377
SICI:
0021-9967(19990607)408:3<365:AAISHL>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; FACTOR-LIKE IMMUNOREACTIVITY; MESSENGER-RNA EXPRESSION; MONKEY SAIMIRI-SCIUREUS; FACTOR CRF RECEPTORS; ADULT-RAT BRAIN; RHESUS-MONKEY; FUNCTIONAL EXPRESSION; MACACA-FASCICULARIS; SQUIRREL-MONKEY;
Keywords:
corticotropin-releasing factor; rhesus monkey; sauvagine; pituitary; prefrontal cortex; locus coeruleus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Sanchez, MM Emory Univ, Sch Med, Dept Psychiat & Behav Sci, 1639 Pierce Dr, Atlanta, GA Emory Univ 1639 Pierce Dr Atlanta GA USA 30322 Dr, Atlanta, GA
Citazione:
M.M. Sanchez et al., "Autoradiographic and in situ hybridization localization of corticotropin-releasing factor 1 and 2 receptors in nonhuman primate brain", J COMP NEUR, 408(3), 1999, pp. 365-377

Abstract

Two different corticotropin-releasing factor (CRF) receptors, CRF1 and CRF2, have been identified in rat and human brain. Although the two receptor subtypes show a markedly different distribution in the rat brain, their distribution in the primate brain has not been described previously. In this study, the neuroanatomic distribution of CRF1 and CRF2 receptor binding sitesin rhesus monkey (Macaca mulatta) was assessed by using iodine 125 ([I-125)-Tyr(0)] -sauvagine with or without the selective CRF1 receptor antagonistCP-154,526-1. Radiolabeled human cRNA probes were used to map the distribution of the two receptor mRNAs with in situ hybridization. Both CRF1 and CRF2 receptors were found in the pituitary and throughout the neocortex (especially, in prefrontal, cingulate, striate, and insular cortices), amygdala,and hippocampal formation of the monkey brain. This is in contrast to the distribution of these receptors reported in the rat brain, in which generally only the CRF1 receptor is found in the pituitary and neocortex. These results suggest that, in primates, both CRF1 and CRF2 receptors may be involved in mediating the effects of CRF on cognition, behavior, and pituitary-adrenal function. The presence of CRF1 (but not CRF2) receptors within the locus coeruleus, cerebellar cortex, nucleus of the solitary tract, thalamus, and striatum and of CRF2 (but not CRF1) receptors in the choroid plexus, certain hypothalamic nuclei, the nucleus prepositus, and the nucleus of the stria terminalis suggests that each receptor subtype also may have distinct functional roles within the primate central nervous system. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 00:53:04