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Titolo:
Comparison of gadopentetate dimeglumine and albumin-(Gd-DTPA)(30) for microvessel characterization in an intracranial glioma model
Autore:
Ostrowitzki, S; Fick, J; Roberts, TPL; Wendland, MF; Aldape, KD; Mann, JS; Israel, MA; Brasch, RC;
Indirizzi:
UnivACalif San Francisco, Dept Radiol, Contrast Media Lab, San Francisco, C Univ Calif San Francisco San Francisco CA USA 94143 Lab, San Francisco, C
Titolo Testata:
JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING
fascicolo: 4, volume: 8, anno: 1998,
pagine: 799 - 806
SICI:
1053-1807(199807/08)8:4<799:COGDAA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-VOLUME; CONTRAST-ENHANCED MR; VASCULAR-PERMEABILITY FACTOR; BRAIN-BARRIER PERMEABILITY; ENDOTHELIAL GROWTH-FACTOR; TUMOR ANGIOGENESIS; CAPILLARY-PERMEABILITY; GD-DTPA; MEDIA; MACROMOLECULES;
Keywords:
dynamic MRI; malignant (9L) glioma; quantitative microvascular permeability; fractional blood volume; MR contrast agents; comparative study;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Brasch, RC UnivACalif San Francisco, Dept Radiol, Contrast Media Lab, San Francisco, C Univ Calif San Francisco San Francisco CA USA 94143 ancisco, C
Citazione:
S. Ostrowitzki et al., "Comparison of gadopentetate dimeglumine and albumin-(Gd-DTPA)(30) for microvessel characterization in an intracranial glioma model", J MAGN R I, 8(4), 1998, pp. 799-806

Abstract

To compare the performance of macromolecular albumin gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA)(30) and low molecular weight gadopentetate dimeglumine for microvessel characterization, we examined an intracranial 9L glioma model in which increased angiogenesis, hypervascularity, and hyperpermeability mimic characteristics of clinical malignant brain tumors. Dynamic MRI data were analyzed using a bidirectional, two-compartment kinetic model to extract quantitative estimates for fractional blood volume (fBV) and permeability surface area product (PS), Three criteria were used for comparison of contrast agent performance: (a) tumor conspicuity, defined asthe contrast-to-noise ratio (CNR); (b) dynamic range of differential permeability estimates between tumor and normal brain; (c) reasonableness of blood volume estimates. Gadopentetate was superior to macromolecular albumin-(Gd-DTPA)(30) for detection of 9L brain gliomas and for measurements of hyperpermeability.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 07:14:48