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Titolo:
In vivo quantitative mapping of cardiac perfusion in rats using a noninvasive MR spin-labeling method
Autore:
Belle, V; Kahler, E; Waller, C; Rommel, E; Voll, S; Hiller, KH; Bauer, WR; Haase, A;
Indirizzi:
Univ Wurzburg, Inst Phys, D-97074 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97074 t Phys, D-97074 Wurzburg, Germany
Titolo Testata:
JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING
fascicolo: 6, volume: 8, anno: 1998,
pagine: 1240 - 1245
SICI:
1053-1807(199811/12)8:6<1240:IVQMOC>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; CONTRAST AGENTS; ARTERIAL WATER; INVERSION; QUANTIFICATION; RELAXATION; HEART; T1; CAPILLARIES; EXCHANGE;
Keywords:
1H MRI; spin labeling; perfusion; myocardial blood flow;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Kahler, E Univ Wurzburg, Inst Phys, Hubland, D-97074 Wurzburg, Germany Univ Wurzburg Hubland Wurzburg Germany D-97074 urzburg, Germany
Citazione:
V. Belle et al., "In vivo quantitative mapping of cardiac perfusion in rats using a noninvasive MR spin-labeling method", J MAGN R I, 8(6), 1998, pp. 1240-1245

Abstract

Measurement of myocardial perfusion is important for the functional assessment of heart in vivo. Our approach is based on the modification of the longitudinal. relaxation time T1 induced by magnetic spin labeling of endogenous water protons. Labeling is performed by selectively inverting the magnetization within the detection slice, and longitudinal relaxation is measuredusing a fast gradient echo MRI technique, As a result of blood now, nonexcited spins enter the detection slice, which leads to an acceleration of therelaxation rate. Incorporating this phenomenon in a mathematical model that describes tissue as two compartments yields a simple expression that allows the quantification of perfusion from a slice-selective and a global inversion recovery experiment. This model takes into account the difference between T1 in blood and T1 in tissue. Our purpose was to evaluate the feasibility and reproducibility of this technique to map quantitatively myocardial perfusion in vivo in rats. Quantitative maps of myocardial blood now were obtained from nine rats, and the reproducibility of the technique was evaluated by repeating the whole perfusion experiment four times. Evaluation of regions of interest within the myocardium yielded a mean perfusion value of 3.6 +/- .5 ml.min(-1).g(-1) over all animals, which is in good agreement with previously reported literature values.

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Documento generato il 05/07/20 alle ore 10:11:07