Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The rete mirabile of the eel: A useful model for the study of transcapillary passage of MR contrast agents
Autore:
Siauve, N; Cuenod, CA; Clement, O; Rasio, E; Bendayan, M; Frija, G;
Indirizzi:
Fac Med Necker, Lab Rech Imagerie, Paris, France Fac Med Necker Paris France ed Necker, Lab Rech Imagerie, Paris, France
Titolo Testata:
JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING
fascicolo: 2, volume: 9, anno: 1999,
pagine: 353 - 361
SICI:
1053-1807(199902)9:2<353:TRMOTE>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAPILLARY-PERMEABILITY; GD-DTPA; ENHANCING AGENT; TRANSPORT; ALBUMIN; IMMUNOCYTOCHEMISTRY; PHARMACOKINETICS; MACROMOLECULES; IRRADIATION; MOLECULES;
Keywords:
capillary permeability; magnetic resonance experimental; magnetic resonance contrast media; macromolecular magnetic resonance contrast media; superparamagnetic iron oxide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Frija, G Fac Med Necker, Lab Rech Imagerie, Paris, France Fac Med Necker Paris France , Lab Rech Imagerie, Paris, France
Citazione:
N. Siauve et al., "The rete mirabile of the eel: A useful model for the study of transcapillary passage of MR contrast agents", J MAGN R I, 9(2), 1999, pp. 353-361

Abstract

Our purpose was to study the capillary leakage of MR contrast media using a pure capillary model. the rete mirabile of the eel. The rete is a countercurrent-exchange organ composed of an arterial and a venous capillary system that can be catheterized and perfused. Substances are introduced at the arterial input by a constant Infusion, and their steady-state concentrationsare measured at the arterial and venous outputs, The capillary leakage of four MR contrast agents-Gd-DOTA (MW = 561 D), carboxymethyldextran-Gd-DTPA (MW = 38,900 D), albumin-Gd-DTPA (MW = 92,000 D), AMI-227 (400,000 D < MW <900,000 D)-was characterized by reference to radioactive tracers ((HHO)-H-3, Na-22, C-14-sucrose, I-125-albumin) by two parameters. These parameters were the concentration ratio of the venous output over the arterial input [C-VOUT(%)] and the permeability coefficient (P), The transcapillary pathwaymechanisms for carboxymethyldextran-Gd-DTPA and albumin-Gd-DTPA were studied by electron microscopy, P values for Gd-DOTA (9.4 +/- 3.6 10(-7) cm/s) and albumin-Gd-DTPA (11.8 +/- 5.5 10(-7) cm/s) were close to P values for C-14-sucrose, while P values for carboxymethyldextran-Gd-DTPA (6.4 +/- 4.9 10(-7) cm/sec) were similar to P values for 125I-albumin. The lowest permeability was observed with AMI-227 (2.7 +/- 2 10(-7) cm/sec), Vesicular transport was demonstrated for carboxymethyldextran-Gd-DTPA and albumin-Gd-DTPA. The transcapillary passage of several MR contrast agents can be characterized with the rete mirabile model. Molecular weight is the major factor influencing transport, J. Magn. Reson. Imaging 1999;9:353-361, (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 19:35:14