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Titolo:
OX40-mediated cosignal enhances the maturation of naive human CD4+ T cellsinto high IL-4-producing effectors
Autore:
Delespesse, G; Ohshima, Y; Yang, LP; Demeure, C; Sarfati, M;
Indirizzi:
Univ4M1,treal, Ctr Rech, CHUM, Lab Rech Allergie M4211 K, Montreal, PQ H2LUniv Montreal Montreal PQ Canada H2L 4M1 lergie M4211 K, Montreal, PQ H2L
Titolo Testata:
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
fascicolo: 2-4, volume: 118, anno: 1999,
pagine: 384 - 386
SICI:
1018-2438(199902/04)118:2-4<384:OCETMO>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
OX40 LIGAND; EXPRESSION; RECEPTOR; TH1; DIFFERENTIATION; INTERLEUKIN-4; RESPONSES; PROMOTES;
Keywords:
OX40; IL-4; Th2 cells; naive T cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Delespesse, G Univ,1560real, Ctr Rech, CHUM, Lab Rech Allergie M4211 K, Campus Notre Dame Univ Montreal Campus Notre Dame,1560 Sherbrooke St E Montreal PQ Canada H2L 4M1
Citazione:
G. Delespesse et al., "OX40-mediated cosignal enhances the maturation of naive human CD4+ T cellsinto high IL-4-producing effectors", INT A AL IM, 118(2-4), 1999, pp. 384-386

Abstract

Our previous studies have indicated that naive human CD4+ T cells of neonatal or adult origin may be the initial source of IL-4 which is required fortheir development into Th2 effecters. In addition to minute amounts of IL-4, anti-CD3/B7.1-activated naive cells also release readily detectable levels of IL-13 and IFN-gamma. The production of IL-4 and IL-13 by naive T cells is differentially regulated by TGF-beta and IL-12. Shortly after activation, naive T cells express surface OX40, a TNF-R family member whose ligand (OX40L) is constitutively expressed on a subset of dendritic cells. Engagement of OX40 on activated naive T cells increases their expression of IL-4 and IL-13, suppresses that of IFN-gamma and promotes their development into Th2-like effecters.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:02:35