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Titolo:
Genome-wide scan for autism susceptibility genes
Autore:
Philippe, A; Martinez, M; Guilloud-Bataille, M; Gillberg, C; Rastam, M; Sponheim, E; Coleman, M; Zappella, M; Aschauer, H; van Malldergerme, L; Penet, C; Feingold, J; Brice, A; Leboyer, M;
Indirizzi:
Hop La Pitie Salpetriere, INSERM, U289, F-75013 Paris, France Hop La PitieSalpetriere Paris France F-75013 289, F-75013 Paris, France Univ Paris 07, INSERM, U155, F-75005 Paris, France Univ Paris 07 Paris France F-75005 , INSERM, U155, F-75005 Paris, France Hop St Louis, INSERM, U358, F-75010 Paris, France Hop St Louis Paris France F-75010 s, INSERM, U358, F-75010 Paris, France Hopncebert Debre, Serv Psychopathol Enfant & Adolescent, F-75019 Paris, Fra Hop Robert Debre Paris France F-75019 t & Adolescent, F-75019 Paris, Fra Sahlgrens Univ Hosp, S-41345 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden S-41345 S-41345 Gothenburg, Sweden
Titolo Testata:
HUMAN MOLECULAR GENETICS
fascicolo: 5, volume: 8, anno: 1999,
pagine: 805 - 812
SICI:
0964-6906(199905)8:5<805:GSFASG>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN TRANSPORTER; LINKAGE ANALYSIS; COMPLEX TRAITS; DISORDER; DISEASES; 15Q;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Leboyer, M Hop Henri Mondor, INSERM, U513, 8 Rue Gen Sarrail, F-94010 Creteil, France Hop Henri Mondor 8 Rue Gen Sarrail Creteil France F-94010 ance
Citazione:
A. Philippe et al., "Genome-wide scan for autism susceptibility genes", HUM MOL GEN, 8(5), 1999, pp. 805-812

Abstract

Family and twin studies have suggested a genetic component in autism. We performed a genome-wide screen with 264 microsatellites markers in 51 multiplex families, using non-parametric linkage methods. Families were recruitedby a collaborative group including clinicians from Sweden, France, Norway,the USA, Italy, Austria and Belgium. Using two-point and multipoint affected sib-pair analyses, 11 regions gave nominal P-values of 0.05 or lower. Four of these regions overlapped with regions on chromosomes 2q, 7q, 16p and 19p identified by the first genome-wide scan of autism performed by the International Molecular Genetic Study of Autism Consortium. Another of our potential susceptibility regions overlapped with the 15q11-q13 region identified in previous candidate gene studies. Our study revealed six additional regions on chromosomes 4q, 5p, 6q, 10q, 18q and Xp, We found that the most significant multipoint linkage was close to marker D6S283 (maximum lod score = 2.23, P = 0.0013).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 17:42:02