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Titolo:
Stimulatory effect of zinc acexamate administration on fracture healing ofthe femoral-diaphyseal tissues in rats
Autore:
Igarashi, A; Yamaguchi, M;
Indirizzi:
Univ526,zuoka, Grad Sch Nutr Sci, Lab Endocrinol & Mol Metab, Shizuoka 4228 Univ Shizuoka Shizuoka Japan 4228526 docrinol & Mol Metab, Shizuoka 4228
Titolo Testata:
GENERAL PHARMACOLOGY
fascicolo: 4, volume: 32, anno: 1999,
pagine: 463 - 469
SICI:
0306-3623(199904)32:4<463:SEOZAA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
L-HISTIDINATO ZINC; ALKALINE-PHOSPHATASE ACTIVITY; OSTEOBLASTIC MC3T3-E1 CELLS; TRANSFER-RNA SYNTHETASE; BONE METABOLISM; METAPHYSEAL TISSUES; PROTEIN-SYNTHESIS; BETA; ACTIVATION; COMPONENTS;
Keywords:
zinc; zinc acexamate; bone metabolism; fracture healing; rat femur;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Yamaguchi, M Univizuokaoka, Grad Sch Nutr Sci, Lab Endocrinol & Mol Metab,52-1 Yada, Sh Univ Shizuoka 52-1 Yada Shizuoka Japan 4228526 52-1 Yada, Sh
Citazione:
A. Igarashi e M. Yamaguchi, "Stimulatory effect of zinc acexamate administration on fracture healing ofthe femoral-diaphyseal tissues in rats", GEN PHARM, 32(4), 1999, pp. 463-469

Abstract

The effect of zinc acexamate on fracture healing of the femoral-diaphysealtissues in rats was investigated in vivo. Zinc acexamate (0.3 and 10.0 mg Zn/100 g body weight per day) was orally administered to rats (4 weeks old)surgically fractured the femoral diaphysis for 14 to 28 days. Calcium content and alkaline phosphatase activity in the femoral-diaphyseal tissues were significantly decreased in rats with fracture healing, while bone acid phosphatase activity and protein content were markedly increased. The administration of zinc acexamate (10.0 mg Zn/100 g) for 28 days caused a significant increase in calcium content, alkaline and acid phosphatases activities, protein and deoxyribonucleic acid (DNA) contents in the femoral-diaphyseal tissues of rats with fracture healing. With the lower dose (3.0 mg Zn/100 g), zinc compound had a partial effect on bone components. Femoral mineral density in rats with fracture healing was significantly increased by the administration of zinc acexamate (10.0 mg Zn/100 g) for 28 days. Femoral-diaphyseal zinc content was significantly decreased in rats with fracture healing. This decrease was completely restored by the administration of zinc acexamate (10.0 mg Zn/100 g) for 28 days. The present study suggests that the supplement of zinc compound stimulates fracture healing of the femoral-diaphyseal tissues in rats. (C) 1999 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:17:34