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Titolo:
Direct pharmacological comparison of the muscarinic receptors mediating relaxation and contraction in the rabbit thoracic aorta
Autore:
Sawyer, BD; Bymaster, FP; Calligaro, DO; Falcone, J; Mitch, CH; Ward, JS; Whitesitt, C; Shannon, HE;
Indirizzi:
Eli Lilly & Co, Lilly Corp Ctr, Lilly Res Labs, Indianapolis, IN 46285 USAEli Lilly & Co Indianapolis IN USA 46285 Labs, Indianapolis, IN 46285 USA
Titolo Testata:
GENERAL PHARMACOLOGY
fascicolo: 4, volume: 32, anno: 1999,
pagine: 445 - 452
SICI:
0306-3623(199904)32:4<445:DPCOTM>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG ILEUM; URINARY-BLADDER; SMOOTH-MUSCLE; ACETYLCHOLINE; BINDING; VASODILATATION; ANTAGONISTS; AGONISTS;
Keywords:
muscarinic M-3 receptors; muscarinic M-2 receptors; thoracic aorta (rabbit); muscarinic receptor partial agonists; carbachol; pilocarpine; RS86;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Shannon, HE Eli Lilly & Co, Lilly Corp Ctr, Lilly Res Labs, Indianapolis, IN 46285 USA Eli Lilly & Co Indianapolis IN USA 46285 apolis, IN 46285 USA
Citazione:
B.D. Sawyer et al., "Direct pharmacological comparison of the muscarinic receptors mediating relaxation and contraction in the rabbit thoracic aorta", GEN PHARM, 32(4), 1999, pp. 445-452

Abstract

The purpose of the present studies was to directly compare the pharmacology of the muscarinic cholinergic receptors coupled to carbachol-induced relaxation and contraction of the intact and the endothelium-denuded rabbit thoracic aorta, respectively. The order of potencies of agonists for producingrelaxation in the intact aorta was similar to that for producing contraction in the denuded aorta. In both preparations, the partial agonists pilocarpine, McN-A-343, and RS86 functioned as antagonists, indicating a lack of receptor reserve in both preparations. Further, the pA(2) values for antagonists in both tissues were virtually identical and were consistent with the pharmacology of M-3 receptors. (C) 1999 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:17:48