Catalogo Articoli (Spogli Riviste)
OPAC HELP
Titolo: Negative association between type 1 diabetes and HLA DQB1*0602DQA1*0102 is attenuated with age at onset
Autore: Graham, J; Kockum, I; Sanjeevi, CB; LandinOlsson, M; Nystrom, L; Sundkvist, G; Arnqvist, H; Blohme, G; Lithner, F; Littorin, B; Schersten, B; Wibell, L; Ostman, J; Lernmark, A; Breslow, N; Dahlquist, G;

 Titolo Testata:
 EUROPEAN JOURNAL OF IMMUNOGENETICS
fascicolo: 23,
volume: 26,
anno: 1999,
pagine: 117  127
 SICI:
 09607420(199904/06)26:23<117:NABT1D>2.0.ZU;2U
 Fonte:
 ISI
 Lingua:
 ENG
 Soggetto:
 ISLETCELL; INSULIN AUTOANTIBODIES; GENETICHETEROGENEITY; MELLITUS; IDDM; POPULATION; CHILDHOOD; SUSCEPTIBILITY; CHILDREN; DETERMINANTS;
 Tipo documento:
 Article
 Natura:
 Periodico
 Settore Disciplinare:
 Life Sciences
 Citazioni:
 39
 Recensione:
 Indirizzi per estratti:



 Citazione:
 J. Graham et al., "Negative association between type 1 diabetes and HLA DQB1*0602DQA1*0102 is attenuated with age at onset", EUR J IMM, 26(23), 1999, pp. 117127
Abstract
HLAassociated relative risks of type 1 (insulindependent) diabetes mellitus were analysed in populationbased Swedish patients and controls aged 034 years. The age dependence of HLAassociated relative risks was assessed by likelihood ratio tests of regression parameters in separate logistic regression models for each HLA category. The analyses demonstrated an attenuation with increasing age at onset in the relative risk for the positively associated DQB1*0201A1*0502/B1*0302A1*0301 (DQ2/8) genotype (P = 0.02) and the negatively associated DQB1*0602A1*0102 (DQ6.2) haplotype (P=0.004). Atbirth, DQ6.2positive individuals had an estimated relative risk of 0.03, but this increased to 1.1 at age 35 years. Relative risks for individuals with DQ genotype 8/8 or 8/X or DQ genotype 2/2 or 2/X, where X is any DQ haplotype other than 2, 8 or 6.2, were not significantly agedependent. An exploratory analysis of DQ haplotypes other than 2, 8 and 6.2 suggested that the risk of type 1 diabetes increases with age for DQB1*0604A1*0102 (DQ6.4)and that the peak risk for the negatively associated DQB1*0301A1*0501 haplotype is at age 18 years. There was also weak evidence that the risk for DQB1*0303A1*0301 (DQ9), which has a positive association in the Japanese population, may decrease with age. We speculate that HLADQ alleles have a significant effect on the rate of beta cell destruction, which is acceleratedin DQ2/8positive individuals and inhibited, but not completely blocked, in DQ6.2positive individuals.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 07:45:44