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Titolo:
Factor VIII and other hemostasis variables are related to incident diabetes in adults - The Atherosclerosis Risk in Communities (ARIC) study
Autore:
Duncan, BB; Schmidt, MI; Offenbacher, S; Wu, KK; Savage, PJ; Heiss, G;
Indirizzi:
Univ,Fed Rio Grande Sul, Sch Med, Dept Social Med, BR-90035003 Porto Alegre Univ Fed Rio Grande Sul Porto Alegre RS Brazil BR-90035003 BCPorto Alegre Univ N Carolina, Sch Publ Hlth, Dept Epidemiol, Chapel Hill, NC USA Univ NCarolina Chapel Hill NC USA , Dept Epidemiol, Chapel Hill, NC USA Univ N Carolina, Sch Dent, Dent Res Ctr, Chapel Hill, NC USA Univ N Carolina Chapel Hill NC USA nt, Dent Res Ctr, Chapel Hill, NC USA Univ Texas, Sch Med, Div Hematol, Houston, TX USA Univ Texas Houston TX USA v Texas, Sch Med, Div Hematol, Houston, TX USA NHLBI, Div Epidemiol & Clin Applicat, NIH, Bethesda, MD 20892 USA NHLBI Bethesda MD USA 20892 & Clin Applicat, NIH, Bethesda, MD 20892 USA
Titolo Testata:
DIABETES CARE
fascicolo: 5, volume: 22, anno: 1999,
pagine: 767 - 772
SICI:
0149-5992(199905)22:5<767:FVAOHV>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; VON-WILLEBRAND-FACTOR; INDUCED INSULIN-RESISTANCE; FACTOR-ALPHA; CARDIOVASCULAR-DISEASE; SKELETAL-MUSCLE; GLUCOSE-UPTAKE; BLOOD-FLOW; IN-VIVO; ADIPOSE-TISSUE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Duncan, BB Univ14,d Rio Grande Sul, Sch Med, Dept Social Med, R Ramiro Barcelos 2600-4 Univ Fed Rio Grande Sul R Ramiro Barcelos 2600-414 Porto Alegre RS Brazil BR-90035003 BC
Citazione:
B.B. Duncan et al., "Factor VIII and other hemostasis variables are related to incident diabetes in adults - The Atherosclerosis Risk in Communities (ARIC) study", DIABET CARE, 22(5), 1999, pp. 767-772

Abstract

OBJECTIVE - Our objective was to evaluate whether selected hemostasis variables, some of which may reflect inflammation or endothelial dysfunction, are independently associated with the development of diabetes. RESEARCH DESIGN AND METHODS - We studied a biethnic cohort of 12,330 men and women, 45-64 years of age, of the Atherosclerosis Risk in Communities Study. New cases of diabetes were diagnosed by a reported physician diagnosis, hypoglycemic medication use, or a casual or fasting serum glucose level of greater than or equal to 11.1 or greater than or equal to 7 mmol/l, respectively. RESULTS - Over an average follow-up of 7 years, 1,335 new cases of diabetes were detected. The odds ratios (4th versus Ist quartile) of developing diabetes, adjusted by logistic regression for age, sex, race, study center, family history of diabetes, fasting glucose, physical activity and smoking, were 1.2 (95% CI 1.0-1.5) for fibrinogen and 1.4 (1.1-1.6) for factor VII. Associations for factor VIII, von Willebrand factor, and activated partial thromboplastin time were found to be 1.8 (1.3-2.3), 1.4 (1.1-1.8), and 0.63(0.49-0.82), respectively in women. Although further adjustment for BMI and waist-to-hip ratio diminished the relationships, a highly statistically significant association (P = 0.001) remained for factor VIII (1.6 [1.2-2.1])in women. CONCLUSIONS - Factor VIII and other hemostasis variables are associated with the development of diabetes in middle-aged adults. These findings support a role for inflammation and, particularly in women, endothelial dysfunction in the pathogenesis of type 2 diabetes.

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Documento generato il 05/12/20 alle ore 20:19:37