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Titolo:
Antidiabetic treatment trends in a cohort of elderly people with diabetes - The Cardiovascular Health Study, 1989-1997
Autore:
Smith, NL; Heckbert, SR; Bittner, VA; Savage, PJ; Barzilay, JI; Dobs, AS; Psaty, BM;
Indirizzi:
Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98101 USAUniv Washington Seattle WA USA 98101 Hlth Res Unit, Seattle, WA 98101 USA Univ Washington, Dept Epidemiol, Seattle, WA 98101 USA Univ Washington Seattle WA USA 98101 ept Epidemiol, Seattle, WA 98101 USA Univ Washington, Dept Hlth Serv, Seattle, WA 98101 USA Univ Washington Seattle WA USA 98101 ept Hlth Serv, Seattle, WA 98101 USA Emory Univ, Sch Med, Div Endocrinol, Atlanta, GA USA Emory Univ Atlanta GA USA Univ, Sch Med, Div Endocrinol, Atlanta, GA USA Univ Alabama, Dept Med, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 , Dept Med, Birmingham, AL 35294 USA Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 pt Med, Baltimore, MD 21205 USA NHLBI, Div Epidemiol & Clin Applicat, Bethesda, MD 20892 USA NHLBI Bethesda MD USA 20892 emiol & Clin Applicat, Bethesda, MD 20892 USA
Titolo Testata:
DIABETES CARE
fascicolo: 5, volume: 22, anno: 1999,
pagine: 736 - 742
SICI:
0149-5992(199905)22:5<736:ATTIAC>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMPAIRED GLUCOSE-TOLERANCE; GLYCEMIC CONTROL; MELLITUS; INSULIN; COMPLICATIONS; TROGLITAZONE; PREVALENCE; POPULATION; EFFICACY; THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Smith, NL Univower,Suiten, Dept Med, Cardiovasc Hlth Res Unit, Metropolitan Pk,East T Univ Washington Metropolitan Pk,East Tower,Suite 1360,1730 Minor Seattle WA USA 98101
Citazione:
N.L. Smith et al., "Antidiabetic treatment trends in a cohort of elderly people with diabetes - The Cardiovascular Health Study, 1989-1997", DIABET CARE, 22(5), 1999, pp. 736-742

Abstract

OBJECTIVE - This study characterizes the pharmaceutical treatment of type 2 diabetes from 1989-1990 to 1996-1997 in an elderly cohort. RESEARCH DESIGN AND METHODS - A total of 5,888 adults aged greater than orequal to 65 years were recruited and attended a baseline clinic visit in 1989-1990 (n = 5,201, original cohort) or 1992-1993 (n = 687, African-American [new] cohort) as participants of the Cardiovascular Health Study Fastingserum glucose (FSG) was measured at baseline. Medication use was ascertained by drug inventory at all annual clinic visits. Diabetes was defined at baseline as insulin or oral hypoglycemic agent (OHA) use eras having an FSG greater than or equal to 7.0 mmol/l (126 mg/dl), the current consensus definition of diabetes. RESULTS - A total of 387 (7%) original (FSG = 9.8 mmol/l [177 mg/dl]) and 115 (17%) new (FSG = 10.6 mmol/l [191 mg/dl]) cohort members had pharmacologically treated diabetes at baseline. Among those in the original and in the new cohorts who survived follow-up, respectively, OHA use decreased from 80 to 48% (P < 0.001) and from 67 to 50% (P < 0.003) and insulin use increased from 20 to 33% (P = 0.001) and from 33 to 37% (P = 0.603). There were 396 (8%) original (FSG = 8.8 mmol/l [159 mg/dl]) and 45 (7%) new (FSG = 10.0mmol/l [181 mg/dl]) cohort members with diabetes untreated at baseline. Among them, respectively, OHA use reached 38 and 30% and insulin use reached 6 and 16% in 1996-1997. CONCLUSIONS - Diabetes was common in this elderly cohort, and >80% of treated patients with diabetes at baseline were not achieving fasting glucose goals of less than or equal to 6.7 mmol/l (120 mg/dl). Many untreated at baseline remained untreated after 7 years of follow-up.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 10:05:30