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Titolo:
Hedgehog is required for activation of engrailed during regeneration of fragmented Drosophila imaginal discs
Autore:
Gibson, MC; Schubiger, G;
Indirizzi:
Univ Washington, Dept Zool, Seattle, WA 98195 USA Univ Washington SeattleWA USA 98195 on, Dept Zool, Seattle, WA 98195 USA
Titolo Testata:
DEVELOPMENT
fascicolo: 8, volume: 126, anno: 1999,
pagine: 1591 - 1599
SICI:
0950-1991(199904)126:8<1591:HIRFAO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROXIMAL-DISTAL AXIS; LONG-RANGE ACTION; DECAPENTAPLEGIC GENE; MORPHOGEN GRADIENT; PATTERN REGULATION; CELL DETERMINATION; WINGLESS PROTEIN; LEG DISKS; EXPRESSION; COMPARTMENT;
Keywords:
Drosophila; imaginal disc; pattern regulation; regeneration; duplication; compartment; hedgehog; engrailed; wingless;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Gibson, MC Univ Washington, Dept Zool, Box 351800, Seattle, WA 98195 USA Univ Washington Box 351800 Seattle WA USA 98195 e, WA 98195 USA
Citazione:
M.C. Gibson e G. Schubiger, "Hedgehog is required for activation of engrailed during regeneration of fragmented Drosophila imaginal discs", DEVELOPMENT, 126(8), 1999, pp. 1591-1599

Abstract

Surgically fragmented Drosophila appendage primordia (imaginal discs) engage in wound healing and pattern regulation during short periods of in vivo culture. Prothoracic leg disc fragments possess exceptional regulative capacity, highlighted by the ability of anterior cells to convert to posterior identity and establish a novel posterior compartment. This anterior/posterior conversion violates developmental lineage restrictions essential for normal growth and patterning of the disc, and thus provides an ideal model forunderstanding how cells change fate during epimorphic pattern regulation. Here we present evidence that the secreted signal encoded by hedgehog directs anterior/posterior conversion by activating the posterior-specific transcription factor engrailed in regulating anterior cells. In the absence of hengehog activity, prothoracic leg disc fragments fail to undergo anterior/posterior conversion, but can still regenerate missing anterior pattern elements. We suggest that hedgehog-independent regeneration within the anteriorcompartment (termed integration) is mediated by the positional cues encoded by wingless and decapentaplegic. Taken together, our results provide a novel mechanistic interpretation of imaginal disc pattern regulation and permit speculation that similar mechanisms could govern appendage regeneration in other organisms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:45:20