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Titolo:
Administration of recombinant human stem cell factor (rhSCF) and granulocyte-colony stimulating factor (rhG-CSF) to maternal and fetal rhesus monkeys(Macaca mulatta)
Autore:
Tarantal, AF; Cowan, MJ;
Indirizzi:
Univ Calif Davis, Calif Reg Primate Res Ctr, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 Primate Res Ctr, Davis, CA 95616 USA Univ Calif Davis, Dept Pediat, Davis, CA 95616 USA Univ Calif Davis DavisCA USA 95616 vis, Dept Pediat, Davis, CA 95616 USA Univ Calif San Francisco, Pediat Bone Marrow Transplant Div, San Francisco, Univ Calif San Francisco San Francisco CA USA 94143 t Div, San Francisco,
Titolo Testata:
CYTOKINE
fascicolo: 4, volume: 11, anno: 1999,
pagine: 290 - 300
SICI:
1043-4666(199904)11:4<290:AORHSC>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD PROGENITOR CELLS; HUMAN-PREGNANCY; HUMAN PLACENTA; GROWTH-FACTOR; FASCICULARIS; RECEPTOR; EXPRESSION; MOBILIZATION; CYNOMOLGUS; ULTRASOUND;
Keywords:
fetus; G-CSF; haematopoiesis; monkey; SCF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Tarantal, AF Univ Calif Davis, Calif Reg Primate Res Ctr, Pedrick & Hutchison Rd, Davis, Univ Calif Davis Pedrick & Hutchison Rd Davis CA USA 95616 s,
Citazione:
A.F. Tarantal e M.J. Cowan, "Administration of recombinant human stem cell factor (rhSCF) and granulocyte-colony stimulating factor (rhG-CSF) to maternal and fetal rhesus monkeys(Macaca mulatta)", CYTOKINE, 11(4), 1999, pp. 290-300

Abstract

Studies with recombinant human stem cell factor (rhSCF) and granulocyte-colony stimulating factor (rhc-CSF) have suggested significant clinical utility although little is known regarding the effect of these cytokines when administered during pregnancy. rhSCF (25 mu g/kg/day) +/- rhG-CSF (50 mu g/kg/day) were administered chronically to gravid rhesus monkeys (n = 12) or directly to the rhesus fetus (n = 2) during the second and third trimesters. Maternal/fetal blood samples were collected to assess circulating SCF/G-CSFlevels and complete blood counts compared to non-treated animals (n = 40). Fetal endogenous SCF levels were four-fold greater than the dam (fetus similar to 2500 pg/ml, dam similar to 500 pg/ml), whereas circulating G-CSF was similar in the fetal/maternal compartments (similar to 50-100 pg/ml). There were no adverse effects detected in the fetus or dam as a result of SCF /- G-CSF administration. Although high levels of SCF and G-CSF were achieved in the maternal circulation with maternal administration (SCF: 7000-15 000 pg/ml; G-CSF: 7000-54 000 pg/ml), there was little evidence of placentaltransport or effects on fetal haematopoiesis. In contrast, direct fetal administration of SCF + G-CSF resulted in a rapid rise in fetal neutrophil counts. These studies have shown the monkey to be an excellent model for studying haematopoietic interventions during gestation, and suggest the best approach for achieving haematopoietic changes in the fetus and newborn is by direct in utero administration. (C) 1999 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 18:20:34