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Titolo:
Quantitative and selective analysis of lactose by capillary electrophoresis
Autore:
Altria, K; Ennis, K; Sadler, R;
Indirizzi:
Glaxo Wellcome, Pharmaceut Dev, Ware SG12 0DP, Herts, England Glaxo Wellcome Ware Herts England SG12 0DP Ware SG12 0DP, Herts, England
Titolo Testata:
CHROMATOGRAPHIA
fascicolo: 7-8, volume: 49, anno: 1999,
pagine: 406 - 410
SICI:
0009-5893(199904)49:7-8<406:QASAOL>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ZONE-ELECTROPHORESIS; SYSTEM PEAKS; INJECTION;
Keywords:
capillary electrophoresis; pharmaceutical analysis; lactose;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Altria, K Glaxo Wellcome, Pharmaceut Dev, Park Rd, Ware SG12 0DP, Herts, England Glaxo Wellcome Park Rd Ware Herts England SG12 0DP erts, England
Citazione:
K. Altria et al., "Quantitative and selective analysis of lactose by capillary electrophoresis", CHROMATOGR, 49(7-8), 1999, pp. 406-410

Abstract

A GE method has been validated for the analysis of batches of lactose usedas a pharmaceutical raw material. This method was shown to be selective for lactose and was found to be quantitative. The separation was achieved dueto on-capillary chelation of the lactose with berate ion. The resulting complex was detected at 195nm. An internal standard is employed to improve injection precision and detector linearity. A system peak occurred in the separation and was systematically investigated to show that it was not sample related. The method was validated and successfully submitted to regulatory authorities and is now in routine use in a number of our quality control laboratories.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 05:56:17