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Titolo:
Hepatocyte transplantation - from the beginning to clinical application
Autore:
Markus, PM; Becker, H;
Indirizzi:
UnivyGottingen, Klin & Poliklin Allgemeinchirurg, D-37075 Gottingen, German Univ Gottingen Gottingen Germany D-37075 rurg, D-37075 Gottingen, German
Titolo Testata:
CHIRURG
fascicolo: 2, volume: 70, anno: 1999,
pagine: 162 - 168
SICI:
0009-4722(199902)70:2<162:HT-FTB>2.0.ZU;2-K
Fonte:
ISI
Lingua:
GER
Soggetto:
MICROCARRIER-ATTACHED HEPATOCYTES; ACUTE LIVER-FAILURE; HEPATOCELLULAR TRANSPLANTATION; HEPATIC-FAILURE; GENE-THERAPY; RAT SPLEEN; GUNN-RATS; PANCREATIC-ISLETS; SYNGENEIC HOSTS; GROWTH-FACTOR;
Keywords:
hepatocyte transplantation; hepatocellular transplantation; experimental animal models; acute and chronic liver failure; hepatocyte implantation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
79
Recensione:
Indirizzi per estratti:
Indirizzo: Markus, PM Univ75ottingen, Klin & Poliklin Allgemeinchirurg, Robert Koch Str 40, D-370 Univ Gottingen Robert Koch Str 40 Gottingen Germany D-37075 70
Citazione:
P.M. Markus e H. Becker, "Hepatocyte transplantation - from the beginning to clinical application", CHIRURG, 70(2), 1999, pp. 162-168

Abstract

Within the past 30 years hepatocyte transplantation has been developed in rodents for the cure of acute and chronic liver failure. Organ shortage andthe enormous costs of orthotopic liver transplantation have promoted intensive research in transplantation of isolated hepatocytes. Transplanted syngeneic hepatocytes survive indefinitively in rodents, allowing correction ofvarious inherited liver enzyme defects or enhancing recipient survival in experimentally induced acute liver failure. The clinical application of hepatocyte transplantation has been recently demonstrated in a young patient suffering from Crigler-Najjar syndrome type I, with successful long-term survival of allogeneic hepatocytes. This review reports the historical development and the published data on experimental and clinical hepatocyte transplantation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/21 alle ore 14:54:16