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Titolo:
Effects of RSR13, a synthetic allosteric modifier of hemoglobin, alone andin combination with dizocilpine, on outcome from transient focal cerebral ischemia in the rat
Autore:
Sarraf-Yazdi, S; Sheng, HX; Grocott, HP; Bart, RD; Pearlstein, RD; Steffen, RP; Warner, DS;
Indirizzi:
Duke Univ, Med Ctr, Dept Anesthesiol, Sch Med, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 Anesthesiol, Sch Med, Durham, NC 27710 USA Washington Univ, Dept Pediat, St Louis, MO 63130 USA Washington Univ St Louis MO USA 63130 Dept Pediat, St Louis, MO 63130 USA Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 v, Med Ctr, Dept Surg, Durham, NC 27710 USA Allos Therapeut, Denver, CO USA Allos Therapeut Denver CO USAAllos Therapeut, Denver, CO USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 2, volume: 826, anno: 1999,
pagine: 172 - 180
SICI:
0006-8993(19990501)826:2<172:EORASA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
CROSS-LINKED HEMOGLOBIN; ARTERY OCCLUSION; BRAIN TEMPERATURE; OXYGEN-AFFINITY; MODEL; STROKE; INJURY; MK-801; BLOOD;
Keywords:
cerebral ischemia; hemoglobin allosteric modification; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Warner, DS DukeSAniv, Med Ctr, Dept Anesthesiol, Sch Med, Box 3094, Durham, NC 27710 U Duke Univ Box 3094 Durham NC USA 27710 3094, Durham, NC 27710 U
Citazione:
S. Sarraf-Yazdi et al., "Effects of RSR13, a synthetic allosteric modifier of hemoglobin, alone andin combination with dizocilpine, on outcome from transient focal cerebral ischemia in the rat", BRAIN RES, 826(2), 1999, pp. 172-180

Abstract

This study examined the effect of a pharmacologically induced rightward shift in the partial pressure of oxygen at which 50% of hemoglobin is saturated (P-50) on outcome from transient focal cerebral ischemia in the rat, Halothane anesthetized rats (n = 20 per group) were given saline or a single 15-min infusion of 150 mg/kg RSR13 (2-[4-[[3,5-dimethylanilino) carbonyl]methyl]phenoxy]-2-methylproprionic acid) intravenously before or 30 min after onset of 75 min of middle cerebral artery filament occlusion (MCAO). Seven days later, severity of hemiparesis and cerebral infarct size were examined. RSR13 alone did not significantly improve outcome. Conscious normothermicrats (n = 12 per group) were also given RSR13 (150 mg/kg) or 0.9% NaCl intravenously and subjected to 75 min of MCAO with 7 days of recovery. Again, RSR13 alone did not significantly reduce infarct size or improve neurologicscore. A dose-response curve for dizocilpine (MK-801) was then constructedin conscious normothermic rats subjected to 75 min of MCAO, Dizocilpine (0.5 mg/kg i.v.) caused a 90% reduction in mean infarct size while 0.25 mg/kgreduced infarct size by 48%, Other rats were then subjected to 75 min of MCAO after being given dizocilpine (0.25 mg/kg i.v.; n = 18) or RSR13 (150 mg/kg i.v.) + dizocilpine (0.25 mg/kg i.v.; n = 15). RSR13 + dizocilpine resulted in smaller cortical infarct volume (8 +/- 14 mm(3) vs, 34 +/- 37 mm(3), p < 0.02) and total cerebral infarct volume (46 +/- 28 mm3 vs. 81 +/- 60mm(3), p < 0.05) compared to dizocilpine alone, respectively, We conclude that a pre-ischemic peak increase in P-50 of similar to 25 mmHg alone is insufficient to reduce focal ischemic injury, but may be advantageous when used in conjunction with other neuroprotective agents. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 19:25:17