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Titolo:
Uncoupling of bone metabolism in rheumatoid arthritis patients with or without joint destruction: Assessment with serum type I collagen breakdown products
Autore:
Garnero, P; Jouvenne, P; Buchs, N; Delmas, PD; Miossec, P;
Indirizzi:
Hop Edouard Herriot, INSERM U403, F-69437 Lyon 3, France Hop Edouard Herriot Lyon France 3 t, INSERM U403, F-69437 Lyon 3, France Hop Edouard Herriot, Dept Immunol, F-69437 Lyon, France Hop Edouard Herriot Lyon France F-69437 pt Immunol, F-69437 Lyon, France Hop Edouard Herriot, Dept Rheumatol, F-69437 Lyon 3, France Hop Edouard Herriot Lyon France 3 Dept Rheumatol, F-69437 Lyon 3, France
Titolo Testata:
BONE
fascicolo: 4, volume: 24, anno: 1999,
pagine: 381 - 385
SICI:
8756-3282(199904)24:4<381:UOBMIR>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
PYRIDINIUM CROSS-LINKS; HORMONE REPLACEMENT THERAPY; POSTMENOPAUSAL WOMEN; URINARY-EXCRETION; DEGRADATION PRODUCTS; DISEASE-ACTIVITY; RESORPTION; MARKERS; IMMUNOASSAY; PYRIDINOLINE;
Keywords:
bone markers; rheumatoid arthritis; type I collagen cross-links; pyridinoline; osteocalcin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Garnero, P Hop Edouard Herriot, INSERM U403, F-69437 Lyon 3, France Hop Edouard Herriot Lyon France 3 403, F-69437 Lyon 3, France
Citazione:
P. Garnero et al., "Uncoupling of bone metabolism in rheumatoid arthritis patients with or without joint destruction: Assessment with serum type I collagen breakdown products", BONE, 24(4), 1999, pp. 381-385

Abstract

In this study we investigate bone metabolism in patients with rheumatoid arthritis (RA), with or without joint destruction, using serum biochemical markers of bone turnover. Three hundred eighteen patients (disease duration > 2 years; mean 9 years) were divided into those with joint destruction, that is, with Larsen wrist X-ray index greater than or equal to 2 (n = 173) and those without joint destruction, that is, with Larsen wrist X-ray index < 2 (n = 145), Bone formation was assessed by serum osteocalcin levels and bone resorption by a new assay for serum type I collagen C-telopeptide breakdown products (serum CTX), Osteocalcin levels were significantly lower in both destructive (-17%) and nondestructive (-22%) groups compared with 319 healthy gender- and age-matched control subjects (p < 0.001 for both groups), but were similar in the two arthritis groups. CTX levels were increased in patients with destructive arthritis compared with controls (+ 35%, p < 0.001), but were not different between those with nondestructive arthritis and controls. In patients with joint destruction, decreased bone formation rate was amplified in those on steroids (n = 72) compared with nonusers (n =101) as demonstrated by lower osteocalcin levels (p = 0.02). CTX levels, but not osteocalcin levels, were positively correlated with indices of disease activity and, moreover, of joint destruction (p < 0.002-0.0001). These results indicate that bone metabolism is uncoupled in patients with RA, Boneformation appears to be reduced both in patients with and without joint destruction, whereas resorption is increased only in patients with joint destruction in relation to disease activity. (C) 1999 by Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 14:55:25