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Titolo:
Different humoral immune response to Chlamydia trachomatis major outer membrane protein variable domains I and IV in Chlamydia-infected patients withor without reactive arthritis
Autore:
Bas, S; Scieux, C; Vischer, TL;
Indirizzi:
Univ Hosp Geneva, Dept Internal Med, Div Rheumatol, Res Lab, CH-1211 Geneva Univ Hosp Geneva Geneva Switzerland 14 heumatol, Res Lab, CH-1211 Geneva St Louis Hosp, Paris, France St Louis Hosp Paris FranceSt Louis Hosp, Paris, France
Titolo Testata:
ARTHRITIS AND RHEUMATISM
fascicolo: 5, volume: 42, anno: 1999,
pagine: 942 - 947
SICI:
0004-3591(199905)42:5<942:DHIRTC>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIGENIC DETERMINANTS; SEROVARS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Bas, S Univ Hosp Geneva, Dept Internal Med, Div Rheumatol, Res Lab, CH-1211 Geneva Univ Hosp Geneva Geneva Switzerland 14 l, Res Lab, CH-1211 Geneva
Citazione:
S. Bas et al., "Different humoral immune response to Chlamydia trachomatis major outer membrane protein variable domains I and IV in Chlamydia-infected patients withor without reactive arthritis", ARTH RHEUM, 42(5), 1999, pp. 942-947

Abstract

Objective. The possibility that some bacterial-specific factor(s) may playa role in triggering Chlamydia trachomatis reactive arthritis was investigated. Methods, Since the variable domains of the major outer membrane protein (MOMP) contain the serovar-determining epitopes of C trachomatis, the abilityof serum IgG to recognize peptides mimicking these epitopes was determinedin 2 groups of infected patients, one with and the other without reactive arthritis. Because asymptomatic C trachomatis infections are frequent, and nonspecific reactions due to inflammation could be observed, this study wasalso performed with samples from healthy blood donors and from patients with inflammatory arthritis unrelated to C trachomatis infection. Results, A predominant reactivity against peptides duplicating the J serovar-specific epitopes was only observed in the group of patients with reactive arthritis. For positive samples, differences between the two groups of Ctrachomatis-infected patients were clearly observed. The mean numbers of positive responses obtained for each of the 7 peptides of the MOMP domain I or each of the 8 peptides of the MOMP domain IV were significantly higher for samples from patients with reactive arthritis (4.7 and 6) than for thosefrom patients with only C trachomatis urogenital infection (1.3 and 2.9). Conclusion. Patients with reactive arthritis had a pattern of reactivitiesthat was compatible with infection by several serotypes of bacteria. Repeated exposures to C trachomatis might therefore be involved in the development of the disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 12:13:59