Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Transient depressive relapse induced by catecholamine depletion - Potential phenotypic vulnerability marker?
Autore:
Berman, RM; Narasimhan, M; Miller, HL; Anand, A; Cappiello, A; Oren, DA; Heninger, GR; Charney, DS;
Indirizzi:
YalewUniv, Sch Med, Clin Neurosci Res Unit, Connecticut Mental Hlth Ctr, Ne Yale Univ New Haven CT USA 06519 es Unit, Connecticut Mental Hlth Ctr, Ne Yale Univ, Sch Med, W Haven Vet Affairs Med Ctr, New Haven, CT 06519 USA Yale Univ New Haven CT USA 06519 Affairs Med Ctr, New Haven, CT 06519 USA Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06519 USA Yale Univ New Haven CT USA 06519 , Dept Psychiat, New Haven, CT 06519 USA
Titolo Testata:
ARCHIVES OF GENERAL PSYCHIATRY
fascicolo: 5, volume: 56, anno: 1999,
pagine: 395 - 403
SICI:
0003-990X(199905)56:5<395:TDRIBC>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-PARA-TYROSINE; ANTIDEPRESSANT-INDUCED REMISSION; CORTICOTROPIN-RELEASING FACTOR; GROWTH-HORMONE RESPONSE; RAT LOCUS-CERULEUS; CEREBROSPINAL-FLUID; MAJOR DEPRESSION; HEALTHY-SUBJECTS; BRAIN; MOOD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Berman, RM Yale Univ, Sch Med, Clin Neurosci Res Unit, Connecticut Mental Hlth Ctr, 34 Yale Univ 34 Pk St New Haven CT USA 06519 t Mental Hlth Ctr, 34
Citazione:
R.M. Berman et al., "Transient depressive relapse induced by catecholamine depletion - Potential phenotypic vulnerability marker?", ARCH G PSYC, 56(5), 1999, pp. 395-403

Abstract

Background: Although state-related alterations in catecholamine function have been well-described in depressed subjects, enduring abnormalities have been less reliably identified. In our study, medication-free subjects with fully remitted major depression underwent a paradigm of catecholamine depletion, via use of the tyrosine hydroxylase inhibitor alpha-methylparatyrosine. Method: Subjects underwent 2 sets of testing conditions in a double-blind,random-ordered, crossover design, approximately 1 week apart. They underwent active catecholamine depletion (via oral administration of 5 g alpha-methylparatyrosine) or sedation-controlled, sham catecholamine depletion (via oral administration of 250 mg diphenhydramine hydrochloride), during a 2-day observation, Serial mood ratings and blood samples were obtained,Results: Fourteen subjects completed the active testing condition; 13 completed sham testing. Subjects experienced marked, transient increases in core depressive and anxiety symptoms, as demonstrated by a mean 21-point increase on Hamilton Depression Rating Scale scores. Furthermore, 10 (71%) of 14subjects fulfilled relapse criteria during active testing, whereas 1 (8%) of 13 subjects did so during sham testing. The severity of the depressive reaction correlated with baseline plasma cortisol levels (r=0.59; P=.04). Conclusions: Euthymic, medication-free subjects with a history of major depression demonstrate significant depressive symptoms when undergoing testing with alpha-methylparatyrosine. This depressive reaction may represent a reliable marker for a history of depression. Further work is needed to clarify the significance of this finding.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:07:17