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Titolo:
Neonatal monoblastic leukemia revealed by specific skin lesions.
Autore:
Rybojad, M; Bredoux, H; Vignon-Pennamen, MD; Prigent, F; Morel, P; Bourrat, E;
Indirizzi:
Hop St Louis, Policlin, Serv Dermatol, F-75010 Paris, France Hop St LouisParis France F-75010 , Serv Dermatol, F-75010 Paris, France
Titolo Testata:
ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE
fascicolo: 2, volume: 126, anno: 1999,
pagine: 157 - 159
SICI:
0151-9638(199902)126:2<157:NMLRBS>2.0.ZU;2-T
Fonte:
ISI
Lingua:
FRE
Soggetto:
CONGENITAL LEUKEMIA; NEWBORN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
7
Recensione:
Indirizzi per estratti:
Indirizzo: Bourrat, E Hops,t Louis, Policlin, Serv Dermatol, 1 Ave Claude Vellefaux, F-75010 Pari Hop St Louis 1 Ave Claude Vellefaux Paris France F-75010 Pari
Citazione:
M. Rybojad et al., "Neonatal monoblastic leukemia revealed by specific skin lesions.", ANN DER VEN, 126(2), 1999, pp. 157-159

Abstract

Background. Specific cutaneous involvement is frequently observed in congenital leukemia and may be the inaugural sign. Lesions may be non-specific and even regress spontaneously, misleading diagnosis and delaying care. Case report. A infant in good health had diffuse ecchymotic maculae at birth which totally regressed within to days. On day 20, a maculous rash and three violet nodules developed. The physical examination found enlarged nodes, liver enlargement and poor general status. Blood cell counts and the myelogram led to the diagnosis of type 5 acute myeloblastic leukemia (AML 5). Search for extension revealed cutaneous leukemia and meningeal and renal involvement. Discussion. The predominance of myelocyte forms is specific for neonatal leukemia (AML 5 and 4). Specific skin lesions are frequent (25 to 30 p. 100 of cases) and sometimes precede (7 p. 100) anomalies in peripheral and medullary smears. Skin biopsy with direct smear can provide rapid diagnosis. Classically subcutaneous nodules or bluish macropapulae give the blueberry muffin baby aspect. The polymorphous features and the remarkably fluctuating skin lesions in our case are unusual, especially since the infant did not have spontaneously reversible neonatal leukemia, a rare unpredictable phenomenon described in new-borns with a normal phenotype which can mislead therapeutic management.

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Documento generato il 06/07/20 alle ore 08:14:42