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Titolo:
Activation of the rostral ventrolateral medulla in an acute anesthetized rodent strychnine model of allodynia
Autore:
Hall, SR; Wang, L; Milne, B; Loomis, C;
Indirizzi:
Queens Univ, Dept Pharmacol & Toxicol, Kingston, ON K7L 3N6, Canada QueensUniv Kingston ON Canada K7L 3N6 icol, Kingston, ON K7L 3N6, Canada Queens Univ, Dept Anaesthesia, Kingston, ON K7L 3N6, Canada Queens Univ Kingston ON Canada K7L 3N6 esia, Kingston, ON K7L 3N6, Canada Mem Univ Newfoundland, Sch Pharm, St Johns, NF, Canada Mem Univ Newfoundland St Johns NF Canada Sch Pharm, St Johns, NF, Canada
Titolo Testata:
ANESTHESIA AND ANALGESIA
fascicolo: 5, volume: 88, anno: 1999,
pagine: 1125 - 1130
SICI:
0003-2999(199905)88:5<1125:AOTRVM>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT LOCUS-COERULEUS; CATECHOLAMINE METABOLISM; INTRATHECAL STRYCHNINE; PULSE VOLTAMMETRY; NEURONS; AFFERENTS; OXIDATION; GLYCINE; ACID; C1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Wang, L Kingstonnada Hosp, Dept Anaesthesia, 76 Stuart St, Kingston, ON K7L 2V7, Ca Kingston Gen Hosp 76 Stuart St Kingston ON Canada K7L 2V7 2V7, Ca
Citazione:
S.R. Hall et al., "Activation of the rostral ventrolateral medulla in an acute anesthetized rodent strychnine model of allodynia", ANESTH ANAL, 88(5), 1999, pp. 1125-1130

Abstract

After the administration of intrathecal strychnine, allodynia is manifested as activation of supraspinal sites involved in pain processing and enhancement of cardiovascular responses evoked by normally innocuous stimuli. Theobjective of this study was to investigate the effect of strychnine-induced allodynia on adrenergic neuronal activity in the C1 area of the rostral ventrolateral medulla (RVLM), a major site involved in cardiovascular regulation. The effect of intrathecal strychnine (40 mu g) or saline followed by repeated hair deflection to caudal lumbar dermatomes in the urethane-anesthetized rat was assessed by measuring voltammetric changes in the RVLM catechol oxidation current (CA . OC), mean arterial pressure (MAP), and heart rate (HR). After the administration of intrathecal strychnine, hair deflection evoked a significant and sustained increase in the RVLM CA . OC and MAP (peak 146.4% +/- 5.6% and 159% +/- 18.4%, of baseline, respectively; P < 0.05). There was a nonsignificant increase in HR (peak 128% +/- 8.2%). In the absence of hair deflection, there was no demonstrable change. Intrathecal saline-treated rats failed to demonstrate changes in RVLM CA . OC, MAP, or HR. In the present study, we demonstrated that, after the administration of intrathecal strychnine, innocuous hair deflection evokes temporally relatedneuronal activation in the rat RVLM and an increase in MAP. This suggests that the RVLM mediates, at least in part, the cardiovascular responses during strychnine allodynia. Implications: Neural injury-associated pain, as manifested by allodynia, is resistant to conventional treatment. In a rat model of allodynia, we demonstrated activation of the brain region involved insympathetic control. Innovative therapies that target this region may be successful in managing this debilitating condition.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/06/20 alle ore 01:24:24