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Titolo:
Development of full-length Trk B-immunoreactive structures in the hippocampal formation of the macaque monkey
Autore:
Hayashi, M; Mitsunaga, F; Ohira, K; Shimizu, K; Yamashita, A;
Indirizzi:
KyotonUniv, Primate Res Inst, Dept Cellular & Mol Biol, Aichi 4848506, Japa Kyoto Univ Aichi Japan 4848506 Cellular & Mol Biol, Aichi 4848506, Japa Nihon Univ, Sch Med, Dept Anat, Tokyo 173, Japan Nihon Univ Tokyo Japan 173 on Univ, Sch Med, Dept Anat, Tokyo 173, Japan
Titolo Testata:
ANATOMY AND EMBRYOLOGY
fascicolo: 6, volume: 199, anno: 1999,
pagine: 529 - 537
SICI:
0340-2061(199906)199:6<529:DOFTBS>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; FACTOR MESSENGER-RNA; TRANSIENT FOREBRAIN ISCHEMIA; LONG-TERM POTENTIATION; GROWTH-FACTOR FAMILY; ADULT-RAT BRAIN; NEUROTROPHIC FACTOR; SYNAPTIC TRANSMISSION; NEURONAL PLASTICITY; CORTICAL-NEURONS;
Keywords:
hippocampus; subiculum; entrhenal cortex; BDNF; NT4/5;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: Hayashi, M KyotonUniv, Primate Res Inst, Dept Cellular & Mol Biol, Aichi 4848506, Japa Kyoto Univ Aichi Japan 4848506 Mol Biol, Aichi 4848506, Japa
Citazione:
M. Hayashi et al., "Development of full-length Trk B-immunoreactive structures in the hippocampal formation of the macaque monkey", ANAT EMBRYO, 199(6), 1999, pp. 529-537

Abstract

Distribution and morphological changes of cells containing the signal transducing neurotrophin receptor, full-length Trk B (fl-Trk B), were investigated in the hippocampal formation of the macaque monkey between embryonic day 140 and the adult stage. Western blot analysis showed that one main protein band, which migrated at 141 kDa, was detected in both the embryonic and adult hippocampal formation. In the pyramidal cells in CA1 and CA3 subfields, the subiculum, and the entorhinal cortex, fl-Trk B-immunoreactive dendrites were observable in the embryonic stage. In contrast, in the granule cells of the dentate gyrus, few dendrites were immunoreactive during embryonicand early developmental stages. This difference may be due to the later growth of the granule cells of the dentate gyrus. The existence of fl-Trk B immunoreactivity in the cell body and dendrites in the embryonic hippocampalneurons, suggests that BDNF and/or NT4/5 act on the hippocampal cells by autocrine/paracrine mechanisms. In the entorhinal cortex, fl-Trk B immunoreactivity became localized in the stellate cells in layer II and the pyramidal cells in layers III,V and VI in adulthood. This indicates that BDNF and/or NT4/5 an important for the maintenance of the projection neurons in the entorhinal cortex at the adult stage. The strongest fl-Trk B immunoreactivity in the hippocampal neurons occurred at postnatal month 4, corresponding to the period of greatest synapse production in the monkey hippocampus, suggesting that BDNF and/or NT4/5 with fl-Trk B may play a role in synapse formation in the monkey hippocampus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 03:23:27