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Titolo:
Dopamine D-4 gene 7-repeat allele and attention deficit hyperactivity disorder
Autore:
Faraone, SV; Biederman, J; Weiffenbach, B; Keith, T; Chu, MP; Weaver, A; Spencer, TJ; Wilens, TE; Frazier, J; Cleves, M; Sakai, J;
Indirizzi:
MassachusettsCGen Hosp, Child Psychiat Serv, Pediat Psychopharmacol Unit AC Massachusetts Gen Hosp Boston MA USA 02114 Pediat Psychopharmacol Unit AC Harvard Univ, Sch Med, Boston, MA USA Harvard Univ Boston MA USAHarvard Univ, Sch Med, Boston, MA USA Harvardton,t Psychiat Epidemiol & Genet, Massachusetts Mental Hlth Ctr, Bos Harvard Inst Psychiat Epidemiol & Genet Boston MA USA ntal Hlth Ctr, Bos Osaka Med Coll, Takatsuki, Osaka, Japan Osaka Med Coll Takatsuki Osaka Japan a Med Coll, Takatsuki, Osaka, Japan Genome Therapuet Inc, Waltham, MA USA Genome Therapuet Inc Waltham MA USA enome Therapuet Inc, Waltham, MA USA Stata Corp, College Stn, TX USA Stata Corp College Stn TX USAStata Corp, College Stn, TX USA
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 5, volume: 156, anno: 1999,
pagine: 768 - 770
SICI:
0002-953X(199905)156:5<768:DDG7AA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
NOVELTY SEEKING; RECEPTOR GENE; DRD4 GENE; ASSOCIATION; POLYMORPHISM; CHILDREN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Biederman, J MassachusettsCGen Hosp, Child Psychiat Serv, Pediat Psychopharmacol Unit AC Massachusetts Gen Hosp 15 Parkman St Boston MA USA 02114 t AC
Citazione:
S.V. Faraone et al., "Dopamine D-4 gene 7-repeat allele and attention deficit hyperactivity disorder", AM J PSYCHI, 156(5), 1999, pp. 768-770

Abstract

Objective: Family, twin, and adoption studies show attention deficit hyperactivity disorder (ADHD) to have a substantial genetic component, and some studies have reported an association between ADHD and the dopamine D-4 (DRD4) gene. Method: The authors recruited 27 triads that comprised an ADHD adult, his or her spouse, and their ADHD child. These triads were assessed forADHD, and their DNA was genotyped for DRD4 alleles. Results: A multiallelic transmission disequilibrium test suggested an association between ADHD and the DRD4 7-repeat allele. Among family members, the number of 7-repeat alleles predicted the diagnosis of ADHD. Conclusions: Prior reports of an association between ADHD and DRD4 generalize to families recruited through clinically referred ADHD adults. However, because there are some conflicting studies, further work is needed to clarify the role of DRD4 in the etiology of the disorder.

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Documento generato il 05/04/20 alle ore 06:42:21