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Titolo:
A worldwide assessment of the frequency of suicide, suicide attempts, or psychiatric hospitalization after predictive testing for Huntington disease
Autore:
Almqvist, EW; Bloch, M; Brinkman, R; Craufurd, D; Hayden, MR;
Indirizzi:
UnivBCritish Columbia, Ctr Mol Med & Therapeut, Dept Med Genet, Vancouver,Univ British Columbia Vancouver BC Canada V5Z 4H4 t Med Genet, Vancouver, Riverview Hosp, Div Geriatr, Port Coquitlam, BC, Canada Riverview Hosp Port Coquitlam BC Canada iatr, Port Coquitlam, BC, Canada St Marys Hosp, Dept Clin Genet, Manchester M13 0JH, Lancs, England St Marys Hosp Manchester Lancs England M13 0JH er M13 0JH, Lancs, England
Titolo Testata:
AMERICAN JOURNAL OF HUMAN GENETICS
fascicolo: 5, volume: 64, anno: 1999,
pagine: 1293 - 1304
SICI:
0002-9297(199905)64:5<1293:AWAOTF>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PSYCHOLOGICAL CONSEQUENCES; DECISION-MAKING; RISK; ATTITUDES; EXPERIENCE; CANCER; GENE; APPLICANTS; DIAGNOSIS; CANADA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Hayden, MR Univ50ritish Columbia, Ctr Mol Med & Therapeut, Dept Med Genet,Room 3024,9 Univ British Columbia Room 3024,950 W 28th Ave Vancouver BC Canada V5Z 4H4
Citazione:
E.W. Almqvist et al., "A worldwide assessment of the frequency of suicide, suicide attempts, or psychiatric hospitalization after predictive testing for Huntington disease", AM J HU GEN, 64(5), 1999, pp. 1293-1304

Abstract

Prior to the implementation of predictive-testing programs for Huntington disease (HD), significant concern was raised concerning the likelihood of catastrophic events (CEs), particularly in those persons receiving an increased-risk result. We have investigated the frequency of CEs-that is, suicide, suicide attempt, and psychiatric hospitalization-after an HD predictive-testing result, through questionnaires sent to predictive-testing centers worldwide. A total of 44 persons (0.97%) in a cohort of 4,527 test participants had a CE: 5 successful suicides, 21 suicide attempts, and 18 hospitalizations for psychiatric reasons. All persons committing suicide had signs of HD, whereas 11 (52.4%) of 21 persons attempting suicide and 8 (44.4%) of 18who had a psychiatric hospitalization were symptomatic, A total of 11 (84.6%) of 13 asymptomatic persons who experienced a CE during the first year after HD predictive testing received an increased-risk result. Factors associated with an increased risk of a CE included (a) a psychiatric history less than or equal to 5 years prior to testing and (b) unemployed status. The frequency of CEs did not differ between those persons receiving results of predictive testing through linkage analysis in whom there was only changes in direction of risk and those persons receiving definitive results after analysis for the mutation underlying HD. These findings provide insights into the frequency, associated factors, and timing of CEs in a worldwide cohort of persons receiving predictive-testing results and, as such, highlight persons for whom ongoing support may be beneficial.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 13:08:01