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Titolo:
Thyroid uptake of liquid versus capsule I-131 tracers in hyperthyroid patients treated with liquid I-131
Autore:
Rini, JN; Vallabhajosula, S; Zanzonico, P; Hurley, JR; Becker, DV; Goldsmith, SJ;
Indirizzi:
New York Hosp, Cornell Med Ctr, Div Nucl Med, New York, NY 10021 USA New York Hosp New York NY USA 10021 Div Nucl Med, New York, NY 10021 USA
Titolo Testata:
THYROID
fascicolo: 4, volume: 9, anno: 1999,
pagine: 347 - 352
SICI:
1050-7256(199904)9:4<347:TUOLVC>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
SODIUM-IODIDE CAPSULES; DISSOLUTION PROFILES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Rini, JN Mem21loan Kettering Canc Ctr, Div Nucl Med, 1275 York Ave, New York, NY 100 Mem Sloan Kettering Canc Ctr 1275 York Ave New York NY USA 10021
Citazione:
J.N. Rini et al., "Thyroid uptake of liquid versus capsule I-131 tracers in hyperthyroid patients treated with liquid I-131", THYROID, 9(4), 1999, pp. 347-352

Abstract

The amount of I-131 used to treat hyperthyroid patients is based in part on the 24-hour thyroid uptake of a diagnostic amount of radioiodine (tracer). We compared the 24-hour uptake of an I-131 tracer administered in liquid or capsule form to the 24-hour uptake of I-131 therapy administered as liquid. Sixty-five hyperthyroid patients with Graves' disease were evaluated and subsequently treated with radioiodine. The liquid group (45 patients) received a liquid I-131 tracer (1.85 MBq [0.05 mCi]) and the capsule group (20patients) received a capsule I-131 tracer (1.63 MBq [0.044 mCi]). Probe calibration factors were the same for the liquid and capsule I-131 standards. All patients received therapeutic amounts of I-131 [114.7-1106.3 MBq [3.1-29.9 mCi]) in liquid form. Therapy uptakes were obtained using the same collimated uptake probe modified with a calibrated lead shield to attenuate the high photon flux. The mean therapeutic uptake was the same for both groups (58%). The mean diagnostic uptake for the capsule group, however, was less than the mean diagnostic uptake for the liquid group (44% vs. 63%). The mean diagnostic uptake for the capsule group was significantly lower than the mean therapeutic uptake for this group (44% vs. 58%), whereas the mean diagnostic and therapeutic uptakes were similar for the group receiving a liquid tracer (63% vs. 58%). In conclusion, diagnostic uptakes performed with a liquid tracer more accurately predicted liquid therapy uptakes than diagnostic uptakes performed with a capsule tracer. This raises concern about the bioavailability of I-131 in capsule form and has implications for determining the amount of I-131 to administer for therapy. Patients whose I-131 therapy was based on the uptake of a capsule tracer received a higher than intended amount of radiation to the thyroid gland.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 13:45:00