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Titolo:
DIFFERENTIAL REGULATION OF DOPAMINE-RECEPTORS AFTER CHRONIC TYPICAL AND ATYPICAL ANTIPSYCHOTIC DRUG-TREATMENT
Autore:
TARAZI FI; FLORIJN WJ; CREESE I;
Indirizzi:
HARVARD UNIV,MCLEAN HOSP,SCH MED,MAILMAN RES CTR BELMONT MA 02178 RUTGERS STATE UNIV,CTR MOL & BEHAV NEUROSCI NEWARK NJ 07102
Titolo Testata:
Neuroscience
fascicolo: 4, volume: 78, anno: 1997,
pagine: 985 - 996
SICI:
0306-4522(1997)78:4<985:DRODAC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; )SPIPERONE-H-3 BINDING-SITES; NAIVE SCHIZOPHRENIC-PATIENTS; RAT-BRAIN; D-4 RECEPTORS; CEREBRAL-CORTEX; AUTORADIOGRAPHIC ANALYSIS; SEROTONIN RECEPTORS; H-3 NEMONAPRIDE; FRONTAL-CORTEX;
Keywords:
ATYPICAL ANTIPSYCHOTICS; AUTORADIOGRAPHY; CHRONIC TREATMENT; DOPAMINE RECEPTORS; SCHIZOPHRENIA; TYPICAL ANTIPSYCHOTICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
68
Recensione:
Indirizzi per estratti:
Citazione:
F.I. Tarazi et al., "DIFFERENTIAL REGULATION OF DOPAMINE-RECEPTORS AFTER CHRONIC TYPICAL AND ATYPICAL ANTIPSYCHOTIC DRUG-TREATMENT", Neuroscience, 78(4), 1997, pp. 985-996

Abstract

Changes in dopamine receptor subtype binding in different brain regions were examined after 28 days treatment of rats with haloperidol, raclopride, clozapine or SCH23390 using in vitro receptor autoradiography. [H-3]7-hydroxy-N,N-di-n-propyl-2-aminotetralin binding to dopamine D-3 receptors was not changed in any brain region by any of the drug treatments. [H-3]SCH23390 was only increased by chronic SCH23390 treatment. Haloperidol significantly increased [H-3]nemonapride and [H-3]spiperone like receptors in the caudate-putamen. In contrast, haloperidol caused a small, significant increase in [H-3]raclopride binding in thelateral caudate-putamen only. Raclopride also elevated, but to a lesser extent [H-3]nemonapride and [H-3]spiperone binding in caudate-putamen, whereas it did not affect [H-3]raclopride binding. Clozapine did not significantly change D-2-like striatal binding of [H-3]nemonapride,[H-3]spiperone or [H-3]raclopride. The differences in radioligand binding suggest that [H-3]nemonapride and [H-3]spiperone may be binding to additional subsets of dopamine D-2-like receptors (including D-4-like receptors) that are not recognized by [H-3]raclopride, which has high affinity for D-2 and D-3 receptors only. Quantification of [H-3]nemonapride or [H-3]spiperone binding in the presence of 300 nM raclopride(to block D-2 and D-3 receptors) revealed that haloperidol, raclopride and clozapine up-regulated D-4-like receptors in the caudate-putamenusing either radioligand. These results suggest that D-4-like receptors may be a common site of action of both typical and atypical antipsychotics. (C) 1997 IBRO. Published by Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 15:02:06