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Titolo:
Trophoblast interferons
Autore:
Roberts, RM; Ealy, AD; Alexenko, AP; Han, CS; Ezashi, T;
Indirizzi:
Univ Missouri, Dept Anim Sci, Anim Sci Res Ctr 158, Columbia, MO 65211 USAUniv Missouri Columbia MO USA 65211 i Res Ctr 158, Columbia, MO 65211 USA Univ Missouri, Dept Biochem, Columbia, MO 65211 USA Univ Missouri Columbia MO USA 65211 Dept Biochem, Columbia, MO 65211 USA
Titolo Testata:
PLACENTA
fascicolo: 4, volume: 20, anno: 1999,
pagine: 259 - 264
SICI:
0143-4004(199905)20:4<259:TI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; BOVINE UTERINE PROTEINS; TAU IFN-TAU; EARLY-PREGNANCY; GENE-EXPRESSION; CHORIONIC-GONADOTROPIN; EXOGENOUS INTERFERON; LUTEINIZING-HORMONE; OVINE ENDOMETRIUM; CERVUS-ELAPHUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Roberts, RM Univ Missouri, Dept Anim Sci, Anim Sci Res Ctr 158, Columbia, MO 65211 USA Univ Missouri Columbia MO USA 65211 8, Columbia, MO 65211 USA
Citazione:
R.M. Roberts et al., "Trophoblast interferons", PLACENTA, 20(4), 1999, pp. 259-264

Abstract

The mechanisms responsible for prevention of corpus luteum regression during early pregnancy are diverse and appear to have arisen in concert with the evolutionary divergence of placental structure. That used by the sub-order Ruminantia is unique and involves the production of a Type I interferon (IFN), IFN-tau (tau). Although IFN-tau resembles other Type I IFNs (such as IFN-alpha, -beta, and -omega) in structure as well as in many of its biological properties, it is not virally inducible and is instead produced constitutively by embryonic trophectoderm during the period immediately prior to implantation. The transcription factor Ets-2 is a component of the regulatory mechanism involved in transcription of IFN-tau. These genes probably arose as the result of a duplication of an IFN-omega gene, 36 million years ago, at about the time the Ruminantia sub-order emerged. They have duplicatedextensively since then and there may be 10 or more genes in some present-day species. The expression of different IFN-tau is unequal and they differ in biological potency. The rapid evolution of IFN-tau genes possibly reflects the placenta as a site of considerable genetic experimentation. (C) 1999W. B. Saunders Company Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 23:47:26