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Titolo:
A conserved motif in group IC3 introns is a new class of GNRA receptor
Autore:
Ikawa, Y; Naito, D; Aono, N; Shiraishi, H; Inoue, T;
Indirizzi:
Kyoto Univ, Fac Sci, Dept Chem, Kyoto 6068502, Japan Kyoto Univ Kyoto Japan 6068502 Fac Sci, Dept Chem, Kyoto 6068502, Japan
Titolo Testata:
NUCLEIC ACIDS RESEARCH
fascicolo: 8, volume: 27, anno: 1999,
pagine: 1859 - 1865
SICI:
0305-1048(19990415)27:8<1859:ACMIGI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROUP-I INTRONS; TETRAHYMENA RIBOZYME; TERTIARY INTERACTIONS; GAAA TETRALOOP; RNA; DOMAIN; EVOLUTION; P5ABC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Inoue, T Kyoto Univ, Fac Sci, Dept Chem, Kyoto 6068502, Japan Kyoto Univ Kyoto Japan 6068502 Dept Chem, Kyoto 6068502, Japan
Citazione:
Y. Ikawa et al., "A conserved motif in group IC3 introns is a new class of GNRA receptor", NUCL ACID R, 27(8), 1999, pp. 1859-1865

Abstract

Terminal tetraloops consisting of GNRA sequences are often found in biologically active large RNAs. The loops appear to contribute towards the organization of higher order RNA structures by forming specific tertiary interactions with their receptors. Group IC3 introns which possess a GAAA loop in the. L2 region often have a phylogenetically conserved motif in their P8 domains. In this report, we show that this, conserved motif stands as a new class of receptor that distinguishes the sequences of GNRA loops less stringently than previously known receptors. The motif can functionally substitutean 11 nt motif receptor in the Tetrahymena ribozyme. Its structural and functional similarity to one class of synthetic receptors obtained from in vitro selection is observed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:47:29