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Titolo:
Tumour response to hypercapnia and hyperoxia monitored by FLOOD magnetic resonance imaging
Autore:
Robinson, SP; Collingridge, DR; Howe, FA; Rodrigues, LM; Chaplin, DJ; Griffiths, JR;
Indirizzi:
Univncendon St Georges Hosp, Sch Med, Div Biochem, CRC,Biomed Magnet Resona Univ London St Georges Hosp London England SW17 0RE Biomed Magnet Resona Mthwoodon Hosp, CRC, Tumor Microcirculat Grp, Gray Lab,Canc Res Trust, Nort Mt Vernon Hosp Northwood Middx England HA6 2JR y Lab,Canc Res Trust, Nort
Titolo Testata:
NMR IN BIOMEDICINE
fascicolo: 2, volume: 12, anno: 1999,
pagine: 98 - 106
SICI:
0952-3480(199904)12:2<98:TRTHAH>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARBOGEN-INDUCED CHANGES; RADIATION RESPONSE; NORMOBARIC OXYGEN; BLOOD-FLOW; TISSUE OXYGENATION; HYPERBARIC-OXYGEN; P-31 MRS; NICOTINAMIDE; RADIOSENSITIVITY; CELLS;
Keywords:
radiotherapy; carbogen; oxygenation; blood flow; MRI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Robinson, SP Univncendon St Georges Hosp, Sch Med, Div Biochem, CRC,BiomedMagnet Resona Univ London St Georges Hosp Cranmer Terrace London England SW17 0RE
Citazione:
S.P. Robinson et al., "Tumour response to hypercapnia and hyperoxia monitored by FLOOD magnetic resonance imaging", NMR BIOMED, 12(2), 1999, pp. 98-106

Abstract

Flow and oxygenation dependent (FLOOD) MR images of GH3 prolactinomas display large intensity increases in response to carbogen (5% CO2/95%O-2) breathing. To assess the relative contributions of carbon dioxide and oxygen to this response and the tumour oxygenation state, the response of GH3 prolactinomas to 5% CO2/95% air, carbogen and 100% O-2 was monitored by FLOOD MRI and pO(2) histography. A 10-30% image intensity increase was observed during 5% CO2/95% air breathing, consistent with an increase in tumour blood flow, as a result of CO2-induced vasodilation, reducing the concentration of deoxyhaemoglobin in the blood. Carbogen caused a further 40-50% signal enhancement, suggesting an additional improvement due to increase blood oxygenation. A small 5-10% increase was observed in response to 100% O-2, highlighting the dominance of CO2-induced vasodilation in the carbogen response. Despite the large FLOOD response, non-significant increases in tumour pO(2) were observed in response to the three gases. Tissue pO(2) is determined by the balance of oxygen supply and demand, hence increased blood flow/oxygenation may not necessarily produce a large increase in tissue pO(2). The FLOODresponse is determined by the level of deoxygenation of blood, the size ofthis response relating to vascular density and the potential of high-oxygen content gases to improve the oxygen supply to tumour tissue. Copyright (C) 1999 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 20:27:32