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Titolo:
The potentiation of amphetamine-induced hyperlocomotion by fimbria-fornix lesions in rats is abolished by intrahippocampal grafts rich in serotonergic neurons
Autore:
Balse, E; Suhr, R; Haaf, A; Kelche, C; Jackisch, R; Cassel, JC;
Indirizzi:
UnivFrance Pasteur Strasbourg 1, CNRS, LN2C, UMR 7521, F-67000 Strasbourg,Univ Louis Pasteur Strasbourg 1 Strasbourg France F-67000 00 Strasbourg, Univrg,eiburg, Inst Pharmakol & Toxikol, Neuropharmakol Lab, D-79104 Freibu Univ Freiburg Freiburg Germany D-79104 europharmakol Lab, D-79104 Freibu
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2, volume: 265, anno: 1999,
pagine: 79 - 82
SICI:
0304-3940(19990416)265:2<79:TPOAHB>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED CORTICOSTERONE SECRETION; STRESS-INDUCED SENSITIZATION; INDUCED LOCOMOTOR-ACTIVITY; BEHAVIORAL SENSITIZATION; NUCLEUS-ACCUMBENS; OPEN-FIELD; DOPAMINE; ACETYLCHOLINE; RELEASE; CORTEX;
Keywords:
amphetamine; fimbria-fornix; locomotion; serotonin; transplants;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Cassel, JC Univ00ouis Pasteur Strasbourg 1, CNRS, LN2C, UMR 7521, 12 Rue Goethe, F-670 Univ Louis Pasteur Strasbourg 1 12 Rue Goethe Strasbourg France F-67000
Citazione:
E. Balse et al., "The potentiation of amphetamine-induced hyperlocomotion by fimbria-fornix lesions in rats is abolished by intrahippocampal grafts rich in serotonergic neurons", NEUROSCI L, 265(2), 1999, pp. 79-82

Abstract

Three-month old Long-Evans female rats were submitted to aspirative lesions of the fimbria-fornix and intrahippocampal grafts of a cell suspension prepared from a region of the fetal brain including the septum and the diagonal band of Broca (rich in cholinergic neurons) or the raphe (rich in serotonergic neurons). A group of lesioned rats was grafted with both suspensionsmixed. Lesion-only and sham-operated rats served as controls. Four months after the lesions, all rats were tested daily for locomotor activity in their home cage, 1 day without being injected, 2 days with an injection of NaCl and 5 days with an injection of 1 mg/kg (i.p.) d-amphetamine. The effectsof the lesions and grafts were assessed by measuring the accumulation of [H-3]-choline or [H-3]-5-hydroxytryptamine (5-MT) by hippocampal slices, andthe electrically-evoked release of tritium. Amphetamine injections produced hyperlocomotion which was potentiated by the lesion. This lesion-induced potentiation was also found in rats with septal grafts, but not in those with raphe or cografts. The uptake and electrically-evoked release of [H-3]-acetylcholine or [H-3]-5-HT were reduced in hippocampal slices from lesion-only rats. In rats which received grafts of septal cells or co-grafts, but not in those with raphe grafts, uptake and release of [H-3]-acetylcholine were close to normal. Uptake and release of [H-3]-5-HT were close to normal in rats with raphe grafts or with co-grafts, but not in those with septal grafts. Altogether, these data suggest that damage to the serotonergic afferents of the hippocampus might play some role in the potentiation of amphetamine-induced hyperlocomotion associated with fimbria-fornix lesions. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:57:35