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Titolo:
Altered spatial patterns of functional thalamocortical connections in the barrel cortex after neonatal infraorbital nerve cut revealed by optical recording
Autore:
Higashi, S; Crair, MC; Kurotani, T; Inokawa, H; Toyama, K;
Indirizzi:
Kyoto Prefectural Univ Med, Dept Physiol, Kamigyo Ku, Kyoto 6028566, JapanKyoto Prefectural Univ Med Kyoto Japan 6028566 Ku, Kyoto 6028566, Japan
Titolo Testata:
NEUROSCIENCE
fascicolo: 2, volume: 91, anno: 1999,
pagine: 439 - 452
SICI:
0306-4522(1999)91:2<439:ASPOFT>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT SOMATOSENSORY CORTEX; VISUAL CORTICAL SLICES; RECEPTOR BLOCKADE; TERMINAL ARBORS; CEREBRAL-CORTEX; ADULT-RAT; LAYER-IV; MOUSE; ORGANIZATION; AXONS;
Keywords:
optical recording; barrel cortex; infraorbital nerve; voltage-sensitive dye; CO staining; thalamocortical slice preparation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Higashi, S Kyotoouji,ectural Univ Med, Dept Physiol, Kamigyo Ku, 456 Kawaramachi Hirok Kyoto Prefectural Univ Med 456 Kawaramachi Hirokouji Kyoto Japan 6028566
Citazione:
S. Higashi et al., "Altered spatial patterns of functional thalamocortical connections in the barrel cortex after neonatal infraorbital nerve cut revealed by optical recording", NEUROSCIENC, 91(2), 1999, pp. 439-452

Abstract

In rodents, the somatosensory cortex has a cell aggregation cluster termedthe barrel, reflecting a whisker vibrissa, and this barrel formation is disrupted by infraorbital nerve cut at birth. In the present study, we prepared thalamocortical slice preparations from rats that received infpaorbital nerve cut either at birth or at postnatal day (P) 7 and those from normal rats, recorded the optical response reflecting neural excitation in the somatosensory cortex with a voltage-sensitive dye (RH482) and compared the optical responses from lesioned rats with those from normal rats. In normal rats at P10, the optical response elicited electrically by thalamic stimulation propagated to the cortex, and then several patchy clusters appeared in layer IV. The size and location of these patchy responses precisely matched either barrels identified by cytochrome oxidase staining or terminal arbors of thalamocortial axons stained with biotinylated dextran amine. In contrast, at P10 in P0-lesioned rats, clusters having a wider horizontal width butsmaller amplitude than those seen in normal rats appeared in layer IV. Correspondingly, neither cytochrome oxidase staining nor biotinylated dextran amine labeling of thalamocortical axons showed any barrel-like clusters or glomerular axon terminals. Likewise, at P5-P6, the tangential width of clusters in layer IV were larger than that in normal rats. At P10 in P7-1esioned rats, small cluster-matched barrels were seen in the optical response as well as in normal rats. These results suggest that P0 infraorbital nerve cut interrupted segregation of functional synapses into the barrels and retarded the maturation of thalamocortical transmission. (C) 1999 IBRO. Published by Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/05/20 alle ore 20:26:01