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Titolo:
Masked assessment of MRI findings: is it possible to differentiate neuro-Behcet's disease from other central nervous system
Autore:
Coban, O; Bahar, S; Akman-Demir, G; Tasci, B; Yurdakul, S; Yazici, H; Serdaroglu, P;
Indirizzi:
Univ Istanbul, Istanbul Med Fac, Dept Neurol, TR-34390 Istanbul, Turkey Univ Istanbul Istanbul Turkey TR-34390 Neurol, TR-34390 Istanbul, Turkey Univ Istanbul, Cerrahpasa Med Fac, Dept Internal Med, Istanbul, Turkey Univ Istanbul Istanbul Turkey Fac, Dept Internal Med, Istanbul, Turkey
Titolo Testata:
NEURORADIOLOGY
fascicolo: 4, volume: 41, anno: 1999,
pagine: 255 - 260
SICI:
0028-3940(199904)41:4<255:MAOMFI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLE-SCLEROSIS; FOLLOW-UP; INVOLVEMENT;
Keywords:
Behcet's syndrome; central nervous system; magnetic resonance imaging; brain, vasculitis; multiple sclerosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Coban, O Univ Istanbul, Istanbul Med Fac, Dept Neurol, TR-34390 Istanbul, Turkey Univ Istanbul Istanbul Turkey TR-34390 R-34390 Istanbul, Turkey
Citazione:
O. Coban et al., "Masked assessment of MRI findings: is it possible to differentiate neuro-Behcet's disease from other central nervous system", NEURORADIOL, 41(4), 1999, pp. 255-260

Abstract

Two neuroradiologists reviewed MRI studies of 34 patients with neuro-Behcet's disease (NBD), 22 with multiple sclerosis (MS) and 7 with systemic lupus erythematosus (SLE) with central nervous system involvement, masked to the clinical diagnosis, age and sex of the patients. Of the patients with NBD12 were in an acute attack; the others had chronic disease. MRI was assessed using a set of criteria, looking at atrophy, the site of discrete parenchymal lesions, regions of predominant involvement and the extent of the lesion(s). The observers also made a guess at the clinical diagnosis. The brain stem and/or basal ganglia were the most predominantly involved sites in all patients with acute NBD; 75% of these lesions were large and confluent, mainly extending from the brain stem to the diencephalon and basal ganglia. However, in chronic cases, the predominant involvement was in the brain stem and/or basal,ganglia in only 36%, and in cerebral hemisphere white matter in another 36%; 27% of these patients showed no parenchymal lesion. Hemisphere white-matter lesions were equally distributed between periventricularand other areas in NBD, while in MS more were periventricular, and in SLE more were nonperiventricular. Brain-stem atrophy was seen in 21% of patients with NBD, with a specificity of 96.5%. In the absence of cortical atrophy, its specificity was 100%. The attempt at making a radiological diagnosis was successful in all cases of acute NBD and 95.5% of patients with MS, butin only 40% of patients with chronic NBD. Most of this latter groups MRI studies were interpreted as MS. An extensive lesion involving the brain stemand basal ganglia seemed to be diagnostic of acute NBD. However, hemisphere white-matter lesions could not be differentiated from those in MS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 13:13:24