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Titolo:
Enhanced release of norepinephrine in rat hippocampus during spontaneous alternation tests
Autore:
Men, DS; McCarty, R; Gold, PE;
Indirizzi:
Univ Virginia, Dept Psychol, Charlottesville, VA 22903 USA Univ Virginia Charlottesville VA USA 22903 Charlottesville, VA 22903 USA
Titolo Testata:
NEUROBIOLOGY OF LEARNING AND MEMORY
fascicolo: 3, volume: 71, anno: 1999,
pagine: 289 - 300
SICI:
1074-7427(199905)71:3<289:ERONIR>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VIVO MICRODIALYSIS; ACETYLCHOLINE-RELEASE; GLUCOSE INJECTIONS; LOCUS-COERULEUS; MEDIAL SEPTUM; EPINEPHRINE MODULATION; INTRASEPTAL MORPHINE; WORKING-MEMORY; AMYGDALA; STRESS;
Keywords:
hippocampus; norepinephrine; behavior; glucose; microdialysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Gold, PE Univ Virginia, Dept Psychol, 102 Gilmer Hall, Charlottesville, VA22903 USA Univ Virginia 102 Gilmer Hall Charlottesville VA USA 22903 03 USA
Citazione:
D.S. Men et al., "Enhanced release of norepinephrine in rat hippocampus during spontaneous alternation tests", NEUROBIOL L, 71(3), 1999, pp. 289-300

Abstract

Recent evidence suggests that release of acetylcholine (ACh) in the hippocampus is associated with performance on a spontaneous alternation task and with enhancement of that performance by systemic and central injections of glucose. The present study extended these findings by examining norepinephrine (NE) release in the hippocampus using in vivo microdialysis while rats were tested for spontaneous alternation performance with and without prior injections (ip) of glucose. Microdialysis samples were collected every 12 min and assayed for NE content by HPLC-ECD. Like ACh, NE release in hippocampus increased during spontaneous alternation testing. As in past experiments, administration of glucose (250 mg/kg) significantly enhanced alternationscores. However, glucose did not influence NE release either during behavioral testing or at rest. These findings contrast with prior evidence showing that glucose augments testing-related increases in ACh release. The findings suggest that norepinephrine is released within the hippocampus while rats are engaged in alternation performance. However, increased release of norepinephrine apparently does not contribute to the enhancement of alternation scores produced by glucose. (C) 1999 Academic Press.

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Documento generato il 07/07/20 alle ore 12:50:04