Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Targeted disruption of the Insl3 gene causes bilateral cryptorchidism
Autore:
Zimmermann, S; Steding, G; Emmen, JMA; Brinkmann, AO; Nayernia, K; Holstein, AF; Engel, W; Adham, IM;
Indirizzi:
Univ Gottingen, Inst Human Genet, D-37073 Gottingen, Germany Univ Gottingen Gottingen Germany D-37073 net, D-37073 Gottingen, Germany Univ Gottingen, Abt Embryol, D-37075 Gottingen, Germany Univ Gottingen Gottingen Germany D-37075 yol, D-37075 Gottingen, Germany Erasmus Univ, NL-3000 DR Rotterdam, Netherlands Erasmus Univ Rotterdam Netherlands NL-3000 DR DR Rotterdam, Netherlands Univermanyrg, Krankenhaus Eppendorf, Abt Mikroskop Anat, D-20251 Hamburg, G Univ Hamburg Hamburg Germany D-20251 Mikroskop Anat, D-20251 Hamburg, G
Titolo Testata:
MOLECULAR ENDOCRINOLOGY
fascicolo: 5, volume: 13, anno: 1999,
pagine: 681 - 691
SICI:
0888-8809(199905)13:5<681:TDOTIG>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
INSULIN-LIKE PEPTIDE; LEY I-L; TESTICULAR DESCENT; SUSPENSORY LIGAMENTS; GROWTH-FACTORS; RECEPTOR GENE; MICE; DIFFERENTIATION; TESTIS; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Adham, IM UnivyGottingen, Inst Human Genet, Gosslerstr 12D, D-37073 Gottingen, German Univ Gottingen Gosslerstr 12D Gottingen Germany D-37073 German
Citazione:
S. Zimmermann et al., "Targeted disruption of the Insl3 gene causes bilateral cryptorchidism", MOL ENDOCR, 13(5), 1999, pp. 681-691

Abstract

The sexual dimorphic position of the gonads in mammals is dependent on differential development of two ligaments, the cranial suspensory ligament (CSL) and the gubernaculum. During male embryogenesis, outgrowth of the gubernaculum and regression of the CSL result in transabdominal descent of the testes, whereas in the female, development of the CSL in conjunction with failure of the gubernaculum development holds the ovaries in a position lateral to the kidneys. Several lines of evidence suggest that regression of the CSL and induction of gubernaculum development are mediated by testosterone and a yet unidentified testicular factor, respectively, The Ins/3 gene (orginally designated Ley I-L), a member of the insulin-like superfamily, is specifically expressed in Leydig cells of the fetal and postnatal testis and in theca cells of the postnatal ovary. Here we show that male mice homozygous for a targeted deletion of the lns/3 locus exhibit bilateral cryptorchidism with free moving testes and genital ducts. These malformations are due to failure of gubernaculum development during embryogenesis, In double-mutant male mice for Ins/3 and androgen receptor genes, testes are positioned adjacent to the kidneys and steadied in the abdomen by the CSL, These findings demonstrate, that the lns/3 induces gubernaculum development in an androgen-independent way, while androgen-mediated regression of the CSL occurs independently from lns/3.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 07:33:28