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Titolo:
Regulation of inflammatory responses to Bordetella pertussis by N-G-monomethyl-L-arginine in mice intranasally infected
Autore:
Torre, D; Speranza, F; Pugliese, A; Fassina, G; Osculati, A; Perversi, L; Banfi, MG; Airoldi, M;
Indirizzi:
Reg Hosp, Div Infect Dis, I-21100 Varese, Italy Reg Hosp Varese Italy I-21100 osp, Div Infect Dis, I-21100 Varese, Italy Univ Pavia, Inst Forens Med, I-27100 Pavia, Italy Univ Pavia Pavia ItalyI-27100 ia, Inst Forens Med, I-27100 Pavia, Italy Univ Pavia, Inst Infect Dis, I-27100 Pavia, Italy Univ Pavia Pavia ItalyI-27100 ia, Inst Infect Dis, I-27100 Pavia, Italy
Titolo Testata:
MEDIATORS OF INFLAMMATION
fascicolo: 1, volume: 8, anno: 1999,
pagine: 25 - 29
SICI:
0962-9351(1999)8:1<25:ROIRTB>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
INORGANIC NITROGEN-OXIDES; NITRIC-OXIDE; MURINE MACROPHAGES; GAMMA-INTERFERON; ACTIVATED MACROPHAGES; LEISHMANIA; GROWTH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Torre, D Reg Hosp, Div Infect Dis, Viale Borri 57, I-21100 Varese, Italy Reg Hosp Viale Borri 57 Varese Italy I-21100 21100 Varese, Italy
Citazione:
D. Torre et al., "Regulation of inflammatory responses to Bordetella pertussis by N-G-monomethyl-L-arginine in mice intranasally infected", MEDIAT INFL, 8(1), 1999, pp. 25-29

Abstract

To investigate effect of MMLA, an inhibitor of nitric oxide (NO) production, on regulation of inflammatory responses to Bordetella pertussis infection, mice were infected intranasally, and treated with various concentrationsof MMLA. Ten days after infection, mice treated with MMLA at dosage of 100mg/kg, given intraperitoneally in a single dose or for 5 consecutive days,showed at histopathologic examination, a significant decrease of intensityof inflammation (scores, 0.6 +/- 0.2 and 0.9 +/- 0.5 respectively). A decrease of cellular accumulation of neutrophils and lymphocytes in the bronchoalveolar lavage (BAL) fluid was observed in infected mice treated with MMLA, especially at dosage of 10 mg/kg, given in a single dose intraperitoneally, In addition, BP-infected mice treated with MMLA (100 mg/kg, intraperitoneally) for 5 consecutive days showed higher mortality rate than untreated mice infected with B. pertussis, and the number of B. pertussis in lungs of mice treated with MMLA was significantly increased. However, MMLA treatmentof infected mice had some effect on levels of IFN-gamma and nitrite/nitrate (end-stable products of NO) in the BAL fluid. This study indicates that NO may play a role either as microbiocidal agent or as a modulator of immuneregulation, inasmuch as it may upregulate tissue inflammatory response to B, pertussis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 19:34:44