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Titolo:
Evaluating virus-transformed cell tumorigenicity
Autore:
Lewis, AM; Alling, DW; Banks, SM; Soddu, S; Cook, JL;
Indirizzi:
NIH, Viral Pathogenesis Sect, Immunopathol Lab, Bethesda, MD 20892 USA NIH Bethesda MD USA 20892 Sect, Immunopathol Lab, Bethesda, MD 20892 USA NIAID, Off Intramural Director, NIH, Bethesda, MD 20892 USA NIAID Bethesda MD USA 20892 ramural Director, NIH, Bethesda, MD 20892 USA Natl Jewish Med & Res Ctr, Dept Med, Robert W Lisle Res Lab Immunol & Tumor Natl Jewish Med & Res Ctr Denver CO USA 80206 sle Res Lab Immunol & Tumor
Titolo Testata:
JOURNAL OF VIROLOGICAL METHODS
fascicolo: 1, volume: 79, anno: 1999,
pagine: 41 - 50
SICI:
0166-0934(199904)79:1<41:EVCT>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYRIAN-HAMSTER CELLS; HETEROGENEITY; INHIBITION; GROWTH;
Keywords:
tumorigenicity; tumorigenicity assays; transformed phenotype; animal models; DNA tumor viruses; adenovirus type 12; simian virus 40;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Lewis, AM US FDA, OVRR, CBER, HFM 400,1401 Rockville Pike, Rockville, MD 20852 USA US FDA HFM 400,1401 Rockville Pike Rockville MD USA 20852 52 USA
Citazione:
A.M. Lewis et al., "Evaluating virus-transformed cell tumorigenicity", J VIROL MET, 79(1), 1999, pp. 41-50

Abstract

The tumorigenicity of adenovirus (Ad) 12-transformed mouse cells was evaluated by analyzing the relationship of tumor cell dose to tumor incidence and tumor latency. The tumor producing dose 50% endpoint values used to define these relationships remained stable during 52 weeks of serial passage in tissue culture and were not determined by low frequency events within the cell population. The data from these analyses suggest that the phenotype of Ad12-transformed mouse cells is influenced by two set of traits-those traits that determine the threshold number of cells required for tumor formationand those that extend the cell dose-dependent tumor latency period. Both traits are established independently of cell immortalization, and both can be influenced by the immunological status of tumor-challenged animals. Theseobservations were verified by using mouse cells transformed by Ad5 and SV40. The biological and molecular processes that contribute to these traits remain to be determined. The approach developed by this analysis provides a reliable, quantitative means of evaluating endogenous traits that determinetransformed cell tumorigenicity. This method can also be used to test the effects of tumor cell manipulations or changes in host response that could alter expression or detection of these neoplastic cell traits. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 10:17:55