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Titolo:
Immunomodulatory effects of chromium (III) in ruminants: A review of potential health benefits and effects on production and milk quality
Autore:
Mallard, BA; Borgs, P; Ireland, MJ; McBride, BW; Brown, BD; Irwin, JA;
Indirizzi:
Univ Guelph, Dept Pathobiol, Guelph, ON N1G 2W1, Canada Univ Guelph Guelph ON Canada N1G 2W1 athobiol, Guelph, ON N1G 2W1, Canada Univ Guelph, Dept Anim & Poultry Sci, Guelph, ON N1G 2W1, Canada Univ Guelph Guelph ON Canada N1G 2W1 ltry Sci, Guelph, ON N1G 2W1, Canada
Titolo Testata:
JOURNAL OF TRACE ELEMENTS IN EXPERIMENTAL MEDICINE
fascicolo: 2, volume: 12, anno: 1999,
pagine: 131 - 140
SICI:
0896-548X(1999)12:2<131:IEOC(I>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
STRESSED FEEDER CALVES; SUPPLEMENTAL DIETARY CHROMIUM; PERIPARTURIENT DAIRY-COWS; EARLY LACTATION; NEUTROPHIL PHAGOCYTOSIS; INSULIN RESPONSIVENESS; TISSUE RESPONSIVENESS; ANTIBODY-RESPONSES; HOLSTEIN COWS; METABOLISM;
Keywords:
chromium; ruminants; insulin; immune response; postreceptor pathways;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Mallard, BA Univ Guelph, Dept Pathobiol, Guelph, ON N1G 2W1, Canada Univ Guelph Guelph ON Canada N1G 2W1 elph, ON N1G 2W1, Canada
Citazione:
B.A. Mallard et al., "Immunomodulatory effects of chromium (III) in ruminants: A review of potential health benefits and effects on production and milk quality", J TR EL EXP, 12(2), 1999, pp. 131-140

Abstract

The immunomodulatory potential of dietary chromium (Cr) has been demonstrated in cattle. Specific Cr-attributed health and production benefits, in both beef and dairy cattle, are postulated to arise in part from the direct and/or indirect consequences of this immunomodulatory potential and from thelong-recognized effects of Cr on insulin and glucose metabolism. Recent studies in dairy heifers evaluated. (1) peripheral tissue responsiveness to insulin following feed supplementation with varying concentrations of Cr-yeast, and (2) blood lymphocyte (BL) insulin receptor expression and binding affinity following dietary supplementation with Cr-chelate. These findings suggest that Cr potentiation of insulin action may be mediated primarily by postreceptor pathways. In addition, in vitro studies examined the effect ofCr-supplemented culture medium on the quantitative expression of several cytokine mRNAs in concanavalin A (ConA)-stimulated bovine BLs. These findings support a previously reported Cr-mediated decrease in interleukin-2 (IL-2) activity in the culture medium of ConA-stimulated BLs from Cr-supplemented cows. They further suggest a role for immunoregulatory cytokines, particularly IL-2, as a mechanism through which Cr exerts its effects upon the bovine immune response. Additionally, the differential inhibition of bacterialgrowth rates by Cr in vitro, simulating possible effects upon anaerobic rumen bacteria populations, suggests a potential indirect mechanism by which dietary Cr may influence ruminant health and performance. The next generation of studies elucidating the cellular and molecular mechanism of Cr immunomodulatory effects will benefit greatly from a reliable, chemically definedsource of Cr bioplexes and from the experience with Cr in ruminants. J. Trace Elem. Exp. Med. 12:131-140, 1999. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 18:39:10