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Titolo:
Recent progress in the detection of the administration of natural hormones: Special focus on Testosterone
Autore:
Segura, J; Peng, SH; de la Torre, X;
Indirizzi:
IMIM, Municipal Inst Med Res, Drug Res Unit, Barcelona, Spain IMIM Barcelona Spain ipal Inst Med Res, Drug Res Unit, Barcelona, Spain
Titolo Testata:
JOURNAL OF TOXICOLOGY-TOXIN REVIEWS
fascicolo: 2, volume: 18, anno: 1999,
pagine: 125 - 144
SICI:
0731-3837(1999)18:2<125:RPITDO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
RATIO MASS-SPECTROMETRY; GAS-CHROMATOGRAPHY; URINARY STEROIDS; DOPING CONTROL; SERUM; DIHYDROTESTOSTERONE; EPITESTOSTERONE; MISUSE; ESTERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Segura, J IMIM, Unitat Farmacol, Av Dr Aiguader 80, Barcelona 08003, SpainIMIM Av Dr Aiguader 80 Barcelona Spain 08003 elona 08003, Spain
Citazione:
J. Segura et al., "Recent progress in the detection of the administration of natural hormones: Special focus on Testosterone", J TOX-TOX R, 18(2), 1999, pp. 125-144

Abstract

Analogues to the normal components of the human body are being administered in sport to increase performance. Criteria to definitively assign an exogenous origin and consequently a doping offence to a high concentration found in doping control are not fully established. Thus, the so called doping by endogenous agents is becoming one of the major challenges in present antidoping policy. Possibility to detect the administration of these endogenous-like substances by means of alterations of known physiological variables (indirect markers) is an interesting approach, distinction from the natural substances present in the body would be a better alternative, if some property is presentthat allows such a distinction. Possibilities that exist at present for detecting testosterone misuse in sport may be taken as an example. This paper reviews some of the important steps developed for testosterone doping detection, starting with indirect markers (parameters of the endogenous steroid profile) in urine and blood. Additionally, direct markers such as detection of testosterone esters (the pharmaceutical form currently abused) in blood are presented. Finally, the potential of isotopic ratio measurements to distinguish among natural and synthetic testosterone is also reviewed. It is expected that the example of testosterone will be useful to suggest future alternatives for the detection of doping by other endogenous substances.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 03:50:27