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Titolo:
FLOTILLIN AND EPIDERMAL SURFACE-ANTIGEN DEFINE A NEW FAMILY OF CAVEOLAE-ASSOCIATED INTEGRAL MEMBRANE-PROTEINS
Autore:
BICKEL PE; SCHERER PE; SCHNITZER JE; OH P; LISANTI MP; LODISH HF;
Indirizzi:
WHITEHEAD INST BIOMED RES,9 CAMBRIDGE CTR CAMBRIDGE MA 02142 WHITEHEAD INST BIOMED RES CAMBRIDGE MA 02142 MASSACHUSETTS GEN HOSP,DEPT MED,DIABET UNIT BOSTON MA 02114 HARVARD UNIV,SCH MED BOSTON MA 02114 HARVARD UNIV,SCH MED BOSTON MA 02114 HARVARD UNIV,SCH MED,DEPT PATHOL BOSTON MA 02215 BETH ISRAEL HOSP BOSTON MA 02215 MIT,DEPT BIOL CAMBRIDGE MA 02139
Titolo Testata:
The Journal of biological chemistry
fascicolo: 21, volume: 272, anno: 1997,
pagine: 13793 - 13802
SICI:
0021-9258(1997)272:21<13793:FAESDA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
GPI-ANCHORED PROTEINS; MOLECULAR-CLONING; LINKED PROTEIN; CELL-SURFACE; TRANSPORT; ADIPOCYTES; SUBDOMAINS; VESICLES; RECEPTOR; DOMAINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
P.E. Bickel et al., "FLOTILLIN AND EPIDERMAL SURFACE-ANTIGEN DEFINE A NEW FAMILY OF CAVEOLAE-ASSOCIATED INTEGRAL MEMBRANE-PROTEINS", The Journal of biological chemistry, 272(21), 1997, pp. 13793-13802

Abstract

Caveolae are plasmalemmal microdomains that are involved in vesiculartrafficking and signal transduction. We have sought to identify novelintegral membrane proteins of caveolae. Here we describe the identification and molecular cloning of flotillin. By several independent methods, flotillin behaves as a resident integral membrane protein component of caveolae. Furthermore, we have identified epidermal surface antigen both as a flotillin homologue and as a resident caveolar protein. Significantly, flotillin is a marker for the Triton-insoluble, buoyantmembrane fraction in brain, where to date mRNA species for known caveolin gene family members have not been detected.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 18:24:18