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Titolo:
Medial frontal cortex involvement in PTSD symptoms: A SPECT study
Autore:
Zubieta, JK; Chinitz, JA; Lombardi, U; Fig, LM; Cameron, OG; Liberzon, I;
Indirizzi:
Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 pt Psychiat, Ann Arbor, MI 48109 USA Univ Michigan, Mental Hlth Res Inst, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 th Res Inst, Ann Arbor, MI 48109 USA Univ Michigan, Div Nucl Med, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 iv Nucl Med, Ann Arbor, MI 48109 USA Ann Arbor Vet Adm Med Ctr, Div Nucl Med, Ann Arbor, MI USA Ann Arbor Vet Adm Med Ctr Ann Arbor MI USA v Nucl Med, Ann Arbor, MI USA
Titolo Testata:
JOURNAL OF PSYCHIATRIC RESEARCH
fascicolo: 3, volume: 33, anno: 1999,
pagine: 259 - 264
SICI:
0022-3956(199905/06)33:3<259:MFCIIP>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTTRAUMATIC-STRESS-DISORDER; CEREBRAL BLOOD-FLOW; POSITRON EMISSION TOMOGRAPHY; YOHIMBINE; HAPPINESS; SADNESS; IMAGERY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Zubieta, JK Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 Ann Arbor, MI 48109 USA
Citazione:
J.K. Zubieta et al., "Medial frontal cortex involvement in PTSD symptoms: A SPECT study", J PSYCH RES, 33(3), 1999, pp. 259-264

Abstract

The regional cerebral blood flow (rCBF) responses to a combat stress-related auditory stimulus was examined in Vietnam veterans diagnosed with posttraumatic stress disorder (PTSD). Based on prior data in healthy subjects, wehypothesized that the medial prefrontal cortex may be involved in the processing of stress responses. Twelve male veterans diagnosed with PTSD, 11 age-matched, combat-exposed subjects without PTSD, and 12 healthy control subjects were studied with single-photon emission tomography and the blood flow tracer [Tc-99m]-HMPAO. Subjects were studied twice, while listening to combat sounds or white noise. Significant increases in the blood flow to the medial prefrontal cortex were observed in PTSD patients, but not in the control groups, which correlated at trend levels with psychophysical measures of stress response. These data support the involvement of the medial prefrontal cortex in the pathophysiology of PTSD, possibly mediating some of its symptoms. (C) 1999 Elsevier Science Ltd. All rights reserved.

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Documento generato il 13/07/20 alle ore 03:15:59