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Titolo:
Changes in elemental concentrations are associated with early stages of apoptosis in human monocyte-macrophages exposed to oxidized low-density lipoprotein: An X-ray microanalytical study
Autore:
Skepper, JN; Karydis, I; Garnett, MR; Hegyi, L; Hardwick, SJ; Warley, A; Mitchinson, MJ; Cary, NRB;
Indirizzi:
Univ Cambridge, Dept Anat, Multiimaging Ctr, Cambridge CB2 3DY, England Univ Cambridge Cambridge England CB2 3DY Ctr, Cambridge CB2 3DY, England Univ Cambridge, Addenbrookes Hosp, Dept Med, Cambridge CB2 2QQ, England Univ Cambridge Cambridge England CB2 2QQ Med, Cambridge CB2 2QQ, England Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England Univ Cambridge Cambridge England CB2 1QP hol, Cambridge CB2 1QP, England St Thomas Hosp, Rayne Inst, Dept Ophthalmol, London SE1 7EH, England St Thomas Hosp London England SE1 7EH phthalmol, London SE1 7EH, England Papworth Hosp, Dept Pathol, Cambridge CB3 8RE, England Papworth Hosp Cambridge England CB3 8RE thol, Cambridge CB3 8RE, England
Titolo Testata:
JOURNAL OF PATHOLOGY
fascicolo: 1, volume: 188, anno: 1999,
pagine: 100 - 106
SICI:
0022-3417(199905)188:1<100:CIECAA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOUSE PERITONEAL-MACROPHAGES; SMOOTH-MUSCLE; CELL-DEATH; HUMAN ATHEROSCLEROSIS; DNA FRAGMENTATION; ICE INHIBITORS; LIPID CORE; CALCIUM; ACTIVATION; MEMBRANE;
Keywords:
apoptosis; X-ray microanalysis; oxidized LDL; Na; K; human monocyte-macrophages; TUNEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Skepper, JN Univ Cambridge, Dept Anat, Multiimaging Ctr, Tennis Court Rd, Cambridge CB2 Univ Cambridge Tennis Court Rd Cambridge England CB2 3DY CB2
Citazione:
J.N. Skepper et al., "Changes in elemental concentrations are associated with early stages of apoptosis in human monocyte-macrophages exposed to oxidized low-density lipoprotein: An X-ray microanalytical study", J PATHOLOGY, 188(1), 1999, pp. 100-106

Abstract

This study examines ion homeostasis in monocyte-macrophages committed to death by apoptosis. S-ray microanalysis has been used to demonstrate that intracellular concentrations of potassium decreased whilst those of sodium increased following 3 h of exposure to 100 mu g/ml of oxidized low-density Lipoprotein (LDL) in vitro. In contrast, the maximal incidence of cell death,as determined by the inability to exclude trypan blue, was not seen until 24 h of exposure. At 12 h, less than 1 per cent of cells were stained usingterminal transferase-mediated DNA nick-end labelling, which is generally accepted as a marker of late stages in the apoptotic pathway. This is the first demonstration of early perturbations of ion homeostasis in monocyte-macrophages exposed to concentrations of oxidized LDL known to cause apoptosis, Copyright (C) 1999 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/02/20 alle ore 12:42:23