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Titolo:
Residual symptoms in depressed patients who respond acutely to fluoxetine
Autore:
Nierenberg, AA; Keefe, BR; Leslie, VC; Alpert, JE; Pava, JA; Worthington, JJ; Rosenbaum, JF; Fava, M;
Indirizzi:
Massachusettsit,n Hosp, Depress Clin & Res Program, Clin Psychopharmacol Un Massachusetts Gen Hosp Boston MA USA 02114 ogram, Clin Psychopharmacol Un
Titolo Testata:
JOURNAL OF CLINICAL PSYCHIATRY
fascicolo: 4, volume: 60, anno: 1999,
pagine: 221 - 225
SICI:
0160-6689(199904)60:4<221:RSIDPW>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR DEPRESSION; DISORDER; REMISSION; RELAPSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Nierenberg, AA Massachusettsit,n Hosp, Depress Clin & Res Program, Clin Psychopharmacol Un Massachusetts Gen Hosp WACC 812,15 Parkman St Boston MA USA 02114
Citazione:
A.A. Nierenberg et al., "Residual symptoms in depressed patients who respond acutely to fluoxetine", J CLIN PSY, 60(4), 1999, pp. 221-225

Abstract

Background: Antidepressants have unequivocal efficacy as compared with placebo, but many patients have residual symptoms despite a robust response toantidepressant therapy. The purpose of this study is to assess residual symptoms in outpatients who respond acutely to fluoxetine. Method: Two hundred and fifteen outpatients with major depressive disorderas assessed with the Structured Clinical Interview for DSM-III-R (SCID-P) were treated openly with fluoxetine 20 mg/day for 8 weeks. One hundred and eight (50.2%) were considered full responders (final 17-item Hamilton Rating Scale for Depression [HAM-D] score less than or equal to 7). Percentages of full responders who continued to have subthreshold or full major depressive disorder symptoms were calculated. The relationship beta een residual symptoms and Axis I and Axis II (assessed with SCID-II for personality disorders) comorbidity was assessed. Results: Of the 108 responders, 19 (17.6%) had no subthreshold or threshold SCID-P major depressive disorder symptoms, while 28 (25.9%) had 1 symptom, and 61 (56.5%) had 2 or more symptoms. No statistically significant relationships were found between number of residual symptoms and selected Axis Icomorbid conditions or total number of Axis II disorders. Conclusion: Less than 20% of full responders to fluoxetine by HAM-D criteria were free of all SCID-P subthreshold and threshold major depressive disorder symptoms after 8 weeks of treatment. While depressed patients benefit from antidepressants, most continue to have some symptoms of depression. The high prevalence of residual symptoms among antidepressant responders suggests the need for further study including whether residual symptoms abate with longer treatment or increased dose of fluoxetine. Other strategies, such as cognitive behavioral therapy, may be needed to address residual symptoms.

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Documento generato il 20/09/20 alle ore 19:27:06