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Titolo:
Sustained hemodynamic effects of the selective dopamine-1 agonist, fenoldopam, during 48-hour infusions in hypertensive patients: A dose-tolerabilitystudy
Autore:
Taylor, AA; Mangoo-Karim, R; Ballard, KD; Luther, RR; Pool, JL;
Indirizzi:
Baylor30oll Med, Dept Med, Sect Hypertens & Clin Pharmacol, Houston, TX 770 Baylor Coll Med Houston TX USA 77030 ns & Clin Pharmacol, Houston, TX 770
Titolo Testata:
JOURNAL OF CLINICAL PHARMACOLOGY
fascicolo: 5, volume: 39, anno: 1999,
pagine: 471 - 479
SICI:
0091-2700(199905)39:5<471:SHEOTS>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEVERE SYSTEMIC HYPERTENSION; BLOOD-PRESSURE REDUCTION; SODIUM-NITROPRUSSIDE; INTRAVENOUS FENOLDOPAM; RECEPTOR AGONIST; MESYLATE; MANAGEMENT; EMERGENCIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Taylor, AA BaylorRooml Med, Dept Med, Sect Hypertens & Clin Pharmacol, 1 Baylor Plaza, Baylor Coll Med 1 Baylor Plaza,Room 802E Houston TX USA 77030 ,
Citazione:
A.A. Taylor et al., "Sustained hemodynamic effects of the selective dopamine-1 agonist, fenoldopam, during 48-hour infusions in hypertensive patients: A dose-tolerabilitystudy", J CLIN PHAR, 39(5), 1999, pp. 471-479

Abstract

Eight patients with stage I-II hypertension received a continuous IV infusion of the selective dopamine-1 agonist, fenoldopam, for up to 48 hours at rates from 0.4 to 1.9 mu g/kg/min. Hemodynamics and clinical symptoms during infusion were compared to the same parameters in the 24-hour periods before and after infusion. Fenoldopam lowered blood pressure and increased heart rate. Greatest changes occurred during the first 12 hours of infusion andgradually returned toward preinfusion values throughout the remaining 36 hours in the six patients who completed 48 hours of infusion. Fenoldopam wasdiscontinued within 2 hours of starting the infusion in two patients who received drug rates of 0.9 mu g/kg/min and 1.9 mu g/kg/min because of precipitous bradycardia. Clinical symptoms noted at fenoldopam doses higher than 0.8 mu g/kg/min were headache, dizziness, diaphoresis, nausea and vomiting,and restlessness. In this pilot study fenoldopam effectively reduced bloodpressure in patients with stage I-II hypertension for up to 48 hours, but fixed-dose infusion rates above 0.8 mu g/kg/min were associated with a highfrequency of clinically significant and often intolerable adverse effects. (C) 1999 the American College of Clinical Pharmacology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:11:50