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Titolo:
Potential of packed column supercritical fluid chromatography for the separation of metoprolol from closely related compounds
Autore:
Gyllenhaal, O; Vessman, J;
Indirizzi:
Astra Hassle AB, Pharmaceut Res & Dev, Analyt Chem, S-43183 Molndal, Sweden Astra Hassle AB Molndal Sweden S-43183 lyt Chem, S-43183 Molndal, Sweden
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY A
fascicolo: 1-2, volume: 839, anno: 1999,
pagine: 141 - 148
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARBON-DIOXIDE; BETA-BLOCKERS; MOBILE PHASE; CHYROSINE-A; RESOLUTION;
Keywords:
packed column supercritical fluid chromatography; metoprolol; beta-blockers;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Gyllenhaal, O Astra Hassle AB, Pharmaceut Res & Dev, Analyt Chem, S-43183 Molndal, Sweden Astra Hassle AB Molndal Sweden S-43183 183 Molndal, Sweden
Citazione:
O. Gyllenhaal e J. Vessman, "Potential of packed column supercritical fluid chromatography for the separation of metoprolol from closely related compounds", J CHROMAT A, 839(1-2), 1999, pp. 141-148

Abstract

Using the present SFC method metoprolol can be separated from 12 analoguesand related compounds within 12 min. It is also possible to detect most ofthese analogues at the 0.1% (w/w) level when added to the pure drug substance. The method is based on SFC with modified carbon dioxide as the mobile phase and a packed 4 mm I.D. diol-modified silica column. The mobile phase modifier is 10% (v/v) methanol containing 0.35 M of acetic acid and 0.07 M of triethylamine. UV detection is performed at 273 nm. The main advantage with the described method over the currently used reversed-phase liquid chromatographic method is the different selectivity, i.e., it is possible to separate and detect isomers that elute close to the metoprolol peak in currently used liquid chromatographic systems. (C) 1999 Elsevier Science B.V. Allrights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 13:40:21