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Titolo:
Acute response of the lung mechanics of the rabbit to hypoxia
Autore:
Sakai, H; Fukui, M; Nakano, Y; Endo, K; Hirai, T; Oku, Y; Mishima, M;
Indirizzi:
Kyotopaniv Hosp, Inst Frontier Med Sci, Dept Expt Pathol, Kyoto 6068397, Ja Kyoto Univ Hosp Kyoto Japan 6068397 Dept Expt Pathol, Kyoto 6068397, Ja Kyoto7,niv Hosp, Inst Frontier Med Sci, Dept Med Syst Control, Kyoto 606839 Kyoto Univ Hosp Kyoto Japan 6068397 Dept Med Syst Control, Kyoto 606839 Kyoto Univ Hosp, Dept Phys Therapeut, Kyoto 6068397, Japan Kyoto Univ Hosp Kyoto Japan 6068397 Phys Therapeut, Kyoto 6068397, Japan Shiga Med Ctr Adults, Shiga 5240022, Japan Shiga Med Ctr Adults Shiga Japan 5240022 tr Adults, Shiga 5240022, Japan McGill Univ, Meakins Christie Labs, Montreal, PQ H2X 2P2, Canada McGill Univ Montreal PQ Canada H2X 2P2 Labs, Montreal, PQ H2X 2P2, Canada
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 1, volume: 86, anno: 1999,
pagine: 306 - 312
SICI:
8750-7587(199901)86:1<306:AROTLM>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTRACTILE INTERSTITIAL-CELLS; RESPIRATORY SYSTEM; IMPEDANCE; HISTAMINE; DOGS; TISSUE;
Keywords:
lung resistance; lung elastance; histamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Sakai, H KyotoawaharaInst Frontier Med Sci, Dept Expt Pathol, Sakyo Ku, 53Shogoin K Kyoto Univ 53 Shogoin Kawahara Cho Kyoto Japan 6068397 Shogoin K
Citazione:
H. Sakai et al., "Acute response of the lung mechanics of the rabbit to hypoxia", J APP PHYSL, 86(1), 1999, pp. 306-312

Abstract

We measured the change in total lung resistance (RL) and that in total lung elastance (EL) induced by hypoxia (n = 7) and compared the results with those by intravenous histamine bolus (n = 5) at three different positive end-expiratory pressure (PEEP) levels (2, 5, and 8 hPa) in open-chest and vagotomized rabbits. The percent increase ratio of RL (PIRR) and EL (PIRE) was defined as the change in RL and EL, respectively, induced by hypoxia compared with that in the normoxic condition, expressed as a percentage. PIR values for the change in RL and EL induced by bolus injection of histamine werealso calculated. The PIRR and PIRE induced by hypoxia and by histamine were positive by a statistically significant amount at every PEEP level, except for the PIRE value at 8-hPa PEEP in the hypoxic challenge. The PIRE-to-PIRR ratio values in the hypoxic challenge at 2-hPa PEEP were significantly larger than those in the histamine challenge (hypoxia: 0.91 +/- 0.23%; histamine: 0.37 +/- 0.065%, P < 0.05). The increase in EL induced by histamine in the acute phase has been reported to be mainly derived from tissue distortion secondary to bronchial constriction. Thus our results suggest that a part of the increase in EL by hypoxia was originated in different parenchymal responses from histamine and imply that this hypoxic response of lung parenchyma is sensitive to the increase in parenchymal tethering at high PEEP levels.

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Documento generato il 19/01/20 alle ore 20:28:48