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Titolo:
Effect of acute normovolemic hemodilution on distribution of blood flow and tissue oxygenation in dog skeletal muscle
Autore:
Hutter, J; Habler, O; Kleen, M; Tiede, M; Podtschaske, A; Kemming, G; Corso, C; Batra, S; Keipert, P; Faithfull, S; Messmer, K;
Indirizzi:
Univ Munich, Klinikum Grosshadern, Inst Surg Res, D-81366 Munich, Germany Univ Munich Munich Germany D-81366 nst Surg Res, D-81366 Munich, Germany UnivyMunich, Klinikum Grosshadern, Inst Anesthesiol, D-81366 Munich, German Univ Munich Munich Germany D-81366 t Anesthesiol, D-81366 Munich, German Alliance Pharmaceut Corp, San Diego, CA 92121 USA Alliance Pharmaceut Corp San Diego CA USA 92121 , San Diego, CA 92121 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 3, volume: 86, anno: 1999,
pagine: 860 - 866
SICI:
8750-7587(199903)86:3<860:EOANHO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUTOLOGOUS BLOOD; STRIATED-MUSCLE; CELL FLOW; MICROSPHERES; REDUCTION; ERROR;
Keywords:
heterogeneity of perfusion; oxygen transport; dog; acute normovolemic hemodilution;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Hutter, J Univ6Munich, Klinikum Grosshadern, Inst Surg Res, Marchioninistr15, D-8136 Univ Munich Marchioninistr 15 Munich Germany D-81366 15, D-8136
Citazione:
J. Hutter et al., "Effect of acute normovolemic hemodilution on distribution of blood flow and tissue oxygenation in dog skeletal muscle", J APP PHYSL, 86(3), 1999, pp. 860-866

Abstract

Acute normovolemic hemodilution (ANH) is efficient in reducing allogenic blood transfusion needs during elective surgery. Tissue oxygenation is maintained by increased cardiac output and oxygen extraction and, presumably, a more homogeneous tissue perfusion. The aim of this study was to investigateblood flow distribution and oxygenation of skeletal muscle. ANH from hematocrit of 36 +/- 3 to 20 +/- 1% was performed in 22 splenectomized, anesthetized beagles (17 analyzed) ventilated with room air. Normovolemia was confirmed by measurement of blood volume. Distribution of perfusion within skeletal muscle was determined by using radioactive microspheres. Tissue oxygen partial pressure was assessed with a polarographic platinum surface electrode. Cardiac index (3.69 +/- 0.79 vs. 4.79 +/- 0.731 min(-1).m(-2)) and muscle perfusion (4.07 +/- 0.44 vs. 5.18 +/- 0.36 ml.100 g(-1).min(-1)) were increased at hematocrit of 20%. Oxygen delivery to skeletal muscle was reduced to 74% of baseline values (0.64 +/- 0.06 vs. 0.48 +/- 0.03 mi O-2.100 g(-1).min(-1)). Nevertheless, tissue PO2 was preserved (27.4 +/- 1.3 vs. 29.9 /- 1.4 Torr). Heterogeneity of muscle perfusion (relative dispersion) was reduced after ANH (20.0 +/- 2.2 vs. 13.9 +/- 1.5%). We conclude that a morehomogeneous distribution of perfusion is one mechanism for the preservation of tissue oxygenation after moderate ANH, despite reduced oxygen delivery.

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Documento generato il 11/07/20 alle ore 17:19:40