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Titolo:
Hindlimb immobilization applied to 21-day-old mdx mice prevents the occurrence of muscle degeneration
Autore:
Mokhtarian, A; Lefaucheur, JP; Even, PC; Sebille, A;
Indirizzi:
Facsiol,St Antoine, INSERM, U153, Atelier Regenerat Neuromusculaire,Lab Phy Fac Med St Antoine Paris France 12 ier Regenerat Neuromusculaire,Lab Phy Coll France, CNRS, URA 1860, Lab Neurobiol Regulat, F-75231 Paris, France Coll France Paris France F-75231 eurobiol Regulat, F-75231 Paris, France
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 3, volume: 86, anno: 1999,
pagine: 924 - 931
SICI:
8750-7587(199903)86:3<924:HIAT2M>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
DUCHENNE MUSCULAR-DYSTROPHY; DIFFERENT LENGTHS; SKELETAL-MUSCLE; CONTRACTILE PROPERTIES; LIMB IMMOBILIZATION; SOLEUS MUSCLE; MOUSE MUSCLE; EXERCISE; FIBERS; PROGRESSION;
Keywords:
dystrophinopathy; muscle regeneration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Sebille, A Facsiol,St Antoine, INSERM, U153, Atelier Regenerat Neuromusculaire,Lab Phy Fac Med St Antoine 27 Rue Chaligny Paris France 12 ire,Lab Phy
Citazione:
A. Mokhtarian et al., "Hindlimb immobilization applied to 21-day-old mdx mice prevents the occurrence of muscle degeneration", J APP PHYSL, 86(3), 1999, pp. 924-931

Abstract

Dystrophin-deficient skeletal muscles of mdx mice undergo their first rounds of degeneration-regeneration at the age of 14-28 days. This feature is thought to result from an increase in motor activity at weaning. In this study, we hypothesize that if the muscle is prevented from contracting, it will avoid the degenerative changes that normally occur. For this purpose, we developed a procedure of mechanical hindlimb immobilization in 3-wk-old mice to restrain soleus (Sol) and extensor digitorum longus (FDL) muscles in the stretched or shortened position. After a 14-day period of immobilization, the striking feature was the low percentage of regenerated (centronucleated) myofibers in Sol and EDL muscles, regardless of the length at which they were fixed, compared with those on the contralateral side (stretched Sol:8.4 +/- 6.5 vs. 46.6 +/- 10.3%, P = 0.0008; shortened Sol: 1.2 +/- 1.6 vs.50.4 +/- 16.4%, P = 0.0008; stretched EDL: 05 +/- 0.5 vs. 32.9 +/- 17.5%, P = 0.002; shortened EDL: 3.3 +/- 3.1 vs. 34.7 +/- 11.1%, P = 0.002). Totalnumbers of myofibers did not change with immobilization. This study shows that limb immobilization prevents the occurrence of the first round of myofiber necrosis in mdx mice and suggests that muscle contractions play a rolein the skeletal muscle degeneration of dystrophin-deficient mdx mouse muscles.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 14:10:46